Development of Validated UV Spectrophotometric Method for Assay of Ozagrel and its Pharmaceutical Formulations

Authors

  • Vishal N Kushare  Professor, Department of Pharmaceutics, N.D.M.V.P.S's Institute of Pharmaceutical Science, Adgaon Nashik, Maharashtra, India
  • Sachin S Kushare  Department of Chemistry, Research Center, HPT arts RYK Science College, Nashik, Maharashtra, India
  • Sagar V Ghotekar  Department of Pharmaceutics, SSDJ College of Pharmacy Chandwad,Nashik, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRSET11841113

Keywords:

Ozagrel, Validation, UV-Spectrophometry.

Abstract

UV Spectrophotometric method was developed and validated for the quantitative determination of Ozagrel in bulk drug and in pharmaceutical formulations. Ozagrel shows the maximum absorbance at 270 nm. Ozagrel follows Beer’s law in the concentration range of 1.0-10.0 µg/ml (r = 0.999). The detection limit (DL) and quantitation limit (QL) were 0.4629 and 1.4027 µg/ml respectively. Accuracy and precision were found to be satisfactory. The developed methods were validated according to ICH guidelines. All the validation parameters were found to be satisfactory accordance with the standard values. Therefore, the proposed method can be used for routine practice for the determination of Ozagrel in assay of bulk drug and pharmaceutical formulations.

References

  1. ICH, Q2 (R1): "Validation of Analytical Procedures: Text and Methodology" In Proceedings the International Conference on Harmonisation; IFPMA, Geneva, 2005.
  2. United State Pharmacopoeia 30-National Formulary 25. In Validation of compendial procedures ,Chapter 1225, 2007, p. 549.
  3. Rui1 JIN, SUN-xiang2 Kao, Zhen1 WANG, HAN Yu-bo1. "Pharmacokinetic Study on Ozagrel in Twelve Healthy Volunteers." Chinese Pharmaceutical Journal, 2006, 41(04), p. 296-298.
  4. Sujit Kumar Debnath, S. Saisivam, Dillip Kumar Dash and Monalisha Debnath, "Development and validation of UV-spectrophotometric methods for quantitative estimation of Prothionamide in pure and pharmaceutical dosage forms", International Current Pharmaceutical Journal, June 2015, 4(7): 402-404

International Journal of Scientific Research in Science, Engineering and Technology

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Published

2018-11-30

Issue

Volume 4, Issue 11, November-December-2018

Section

Research Articles

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How to Cite

[1]
Vishal N Kushare, Sachin S Kushare, Sagar V Ghotekar, " Development of Validated UV Spectrophotometric Method for Assay of Ozagrel and its Pharmaceutical Formulations, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 11, pp.69-77, November-December-2018. Available at doi : https://doi.org/10.32628/IJSRSET11841113