Manuscript Number : IJSRSET151532

Traditional Uses, Phytochemistry and Pharmacological Properties of Garlic (Allium Sativum) and its Biological Active Compounds

Authors(2) :-Azene Tesfaye, Work Mengesha

Garlic has a tremendous pharmacological effects due to its biological active constituent (Allicin and its derivatives) organosulfur compounds. Studies carried out on the chemical composition of the plant show that the most important constituents of this plant are organosulfur compounds such as allicin, diallyl disulphide, S-allylcysteine, and diallyl trisulfide which contribute a vital role in its nutraceutical applications. Garlic is one of the most important bulb vegetables, which is used as spice and flavoring agent for foods Garlic adds to taste of foods as well as it helps to make them digestible. Garlic contains different useful minerals, vitamins and many other substances used for health of human beings. It is rich in sugar, protein, fat, calcium, potassium, phosphorous, sulfur, iodine fiber and silicon in addition to vitamins. It possesses high nutritive value. Furthermore, garlic has pharmaceutical effects and used to cure a vast conditions including blood pressure and cholesterol, cancer, hepatoprotective, antihelmentics, antiinflammatory, antioxidant, antifungal and wound healing, asthma, arthritis, sciatica, lumbago, backache, bronchitis, chronic fever, tuberculosis, rhinitis, malaria, obstinate skin disease including leprosy, leucoderma, discolouration of the skin and itches, indigestion, colic pain, enlargement of spleen, piles, fistula, fracture of bone, gout, urinary diseases, diabetes, kidney stone, anemia, jaundice, epilepsy, cataract and night blindness.

Authors and Affiliations

Azene Tesfaye
Biodiversity research Center, Arba Minh University, Ethiopia
Work Mengesha
Departement of plant Science, Aksum University, Ethiopia

Allicin, Allium Sativum, Organosulfur, Nutraceutical Effects, Pharmaceutical

  1. Ahmad, J. I. (1996). Garlic; a panacea for Health and Good Taste. Nutrition and Food Science Vol, 96 No 1 Pp: 32-35.
  2. Ali M. (1995) Mechanism by which garlic (Allium sativum) inhibits cyclooxygenase activity; Effect of raw versus boiled garlic extract on the synthesis of prostanoids. Prostaglandins Leukot Essent Fatty Acids,Vol 53 ,No 6 Pp:397-400.
  3. Al-Qattan, K. K., Thomson, M., Al-Mutawa’a, S., Al-Hajeri, D., Drobiova, H. & Ali, M. (2006). Nitric oxide mediates the blood-pressure lowering effect of garlic in the rat two-kidney, one-clip model of hypertension. The Journal of Nutrition, 136, 774S-776S.
  4. Amagase, H. (2006). Clarifying the real bioactive constituents of garlic. Journal of Nutrition, Vol, 136, Pp; 716S-725S.
  5. Ameenah GF, Mohamad FM, Anwar HS. A kinetic model for in- vitro intestinal uptake of L-tyrosine and D (+)-glucose across rat everted gut sacs in the presence of Momordica charantia, a medicinal plant used in traditional medicine against diabetes mellitus. J Cell Mol Biol, Vol 3, Pp: 39–44.
  6. Auer W, Eiber A, Hertkorn E, (1990) Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Pract Suppl, Vol 69, Pp; 3-6.
  7. Borek C. (2001) Antioxidant health effects of aged garlic extract. J Nutr. Vol, 131, No 3s Pp; 1010S-5S.
  8. Borek, C. (1998.) Recent Advances on the Nutritional Benefits Accompanying the Use of Garlic as a Supplement. New port Beach, Pp 15-17
  9. Brewster, J.L. (1994) Onion and other vegetable Alliums. CABI international, Wellesbourne, Warwick, University Press, Cambridge, UK. pp.256.
  10. Caporaso N, Smith SM Ing R.H.K. (1983) Antifungal activity in human urine and serum after injestion of garlic. Antimicrobial Agents Chemother, Vol 23, Pp: 700-2.
  11. Edwards S., Sebsebe D. and Inga H. (1997). Flora of Ethiopia and Eritrea.National Herbarium, Addis Ababa University. Vol 6, Pp 101-106.
  12. Eric B. (2010). Garlic and Other Alliums: The Lore and the Science. Cambridge: Royal Society of Chemistry. Pp. 447.
  13. Janet, B. (2008). Garlic: Organic Production. www.attra.ncat.org
  14. Jung YM, Lee SH, Lee DS, You MJ, Chung IK, Cheon WH, et al. Fermented garlic protects diabetic, obese mice when fed a high-fat diet by anti-oxidant effects. Nutr Res, Vol (5):387–96.
  15. Kaschula CH. Hunter R., Parker MI. (2010) Garlic-deri, Vol 36, No1, Pp; 78–85.
  16. Kik C. and KR. Gebhardt R. (2001) Garlic and health. Nutr Metab Cardiovascular Dis, Vol 11 Pp: 57–65.
  17. Koch, H.P. and Lawson, L.D. (1996). Garlic: The science and Therapeutic application of Allium sativum L. and related species. 2nd Edition, Baltimore, Pp; 1-233.
  18. Mikaili P., Maadirad S., Moloudizargari M., Aghajanshakeri Sh and Sarahroodi S. (2013) Therapeutic Uses and Pharmacological Properties of Garlic, Shallot, and Their Biologically Active Compounds. Iran J Basic Med Sci; Vol 16, Pp: 1031-1048.
  19. Milner, J.A. (1996). Garlic: Its anti-carcinogenic and ant tumorigenic properties. Nutrition Reviews Vol, 54 Pp:S82–S86.
  20. Ohnishi S. T. and T. Ohnishi (2001). Vitro Effects of Aged Garlic Extract and Other Nutritional Supplements on Sickle Erythrocytes J. Nutr. vol. 131, No, 3, Pp; 1085S-1092S.
  21. Oshiba S, Sawai H, Tamada T, (1990). Inhibitory effect of orally administered inclusion complex of garlic oil on platelet aggregation in man. Igaku no Ayuma, Vol 155, No, 3, Pp; 199-200.
  22. Pendbhaje I. S., Amit P., Shahin M.. Pathan, S., Raotole A, and Pattewar S.V. (2011) Ethnopharmacoloy, Pharmacogosy and Phytochemical Profile of Allium Sativum L. AReview. Pharmacology online, Vol, 2, Pp: 845-85.
  23. Prafulla M., Rahul M., Kavita A. (2011) Medicinal properties of Allium sativum (garlic): a review ijprd/2011/pub/arti/vov-3/issue-2/April/017.
  24. Pulseglove, J.W. (1972) Tropical Crops Monocotyledons. Longman Gorup Limited, London. Pp. 607.
  25. Rubatzky, V.E. and M. Yamaguchi. 1997. World Vegetbales: Principles, Production, and Nutritive Values. Chapman & Hall. New York. Pp 572.
  26. Shela G, Maria L, Hanna L. (2006) Supplementation of garlic lowers lipids and increases antioxidant capacity in plasma of rats. Nutr Res, Vol 26 Pp; 362–368.
  27. Silagy CA, Neil HA.(1994) A meta-analysis of the effect of garlic on blood pressure. J Hypertens, Vol,12, Pp; 463-8.
  28. Srivastava KC, Tyagi OD. (1993). Effects of a garlic-derived principle (ajoene) on aggregation and arachidonic acid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids, Vol.49 No, 2 Pp; 587-595
  29. Sterling S.J. and Eagling D.R (2010) Agronomic and Allicin yield of Australian grown garlic. Acta Horticult. Vol 555, Pp; 63 - 73.
  30. Supplement. NewportBeach, CA. November 15-17, 1998.
  31. Velisek J, Kubec R and Davidek J. (1997) Chemical composition and classification of culinary and pharmaceutical garlic-based products. Z. Lebensem Unters Forsch Vol 24, No 2: Pp: 161 - 4.
  32. Warrier, P. K., Nambiar, V. P. K. and Ramankutty, C. (1995). Indian Medicinal Plants. Vol. 1-5
  33. Yangha Kim M-SL, Kim L-S, Lee HS. (2007) Garlic decreases body weight via decrease of serum lipid and increase of uncoupling proteins mRNA expression. FASEB J., Vol, 21, Pp; 1.

Publication Details

Published in : Volume 1 | Issue 5 | September-October 2015
Date of Publication : 2015-09-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 142-148
Manuscript Number : IJSRSET151532
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Azene Tesfaye, Work Mengesha, " Traditional Uses, Phytochemistry and Pharmacological Properties of Garlic (Allium Sativum) and its Biological Active Compounds, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 5, pp.142-148, September-October-2015.
Journal URL : http://ijsrset.com/IJSRSET151532

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