Developments of HPLC Method for Determination of Methyl Dopa

Authors

  • Hussein Hassan Kharnoob  College Pharmacy, Tikrit University, Tikrit, Iraq

Keywords:

Chromatography, Methy Dopa, Acetonitrile, Drug

Abstract

This research  contains  the development of accurate and quick method for determination  methyldopa drug using high performance  liquid  chromatographic technique, injected 20 μl of the drug solution with concentration 20 μg/ml using a column type C18 , mobile phase consists of  Acetonitrile: 0.02M KH2PO4 (70 : 30) at flow rate of 1.6 m1/min using UV detector at 275nm, pH5.65 ,with retention time 2.89min at linear range 10 – 50μg/ml with good accuracy and precision . The recovery value is to 99.2%and detection limit of 0.05 μg/ ml. The method is applied successfully to determine methyl dopa in its pharmaceutical formulations.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2015-12-25

Issue

Volume 1, Issue 6, November-December-2015

Section

Research Articles

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How to Cite

[1]
Hussein Hassan Kharnoob, " Developments of HPLC Method for Determination of Methyl Dopa, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 6, pp.22-28, November-December-2015.