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Life Cycle of Leishmania Donovani; causative agent of visceral leishmaniasis : A Review


Heena Sachdeva
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Leishmaniasis is transmitted by the bite of infected female phlebotomine sandflies. The sandflies inject the infective stage (i.e., promastigotes) from their proboscis during blood meals. Promastigotes that reach the puncture wound are phagocytized by macrophages and other types of mononuclear phagocytic cells. Promastigotes transform in these cells into the tissue stage of the parasite (i.e., amastigotes) , which multiply by simple division and proceed to infect other mononuclear phagocytic cells. Parasite, host, and other factors affect whether the infection becomes symptomatic and whether cutaneous or visceral leishmaniasis results. Sandflies become infected by ingesting infected cells during blood meals. In sandflies, amastigotes transform into promastigotes, develop in the gut and migrate to the proboscis.

Heena Sachdeva

Phlebotomine, Sandflies, Amastigotes, Promastigotes, Leishmaniasis

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Publication Details

Published in : Volume 2 | Issue 1 | January-Febuary - 2016
Date of Publication Print ISSN Online ISSN
2016-02-25 2395-1990 2394-4099
Page(s) Manuscript Number   Publisher
84-85 IJSRSET162121   Technoscience Academy

Cite This Article

Heena Sachdeva, "Life Cycle of Leishmania Donovani; causative agent of visceral leishmaniasis : A Review", International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 2, Issue 1, pp.84-85, January-Febuary-2016.
URL : http://ijsrset.com/IJSRSET162121.php