Fifth generation cephalosporins: Drugs to overcome antibiotic resistance

Authors

  • Nisha A. R.  Assistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal sciences, Pookode, Wayanad, Kerala, India
  • Vanishree H.  MVSc Scholars Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal sciences, Pookode, Wayanad, Kerala, India
  • Mahesh D. M.  MVSc Scholars Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal sciences, Pookode, Wayanad, Kerala, India

Keywords:

Cephalosporium, VAP, HAP, QIDP, FDA, CABP, ABSSI, MRSA, MSSA, ESBL, ABSSSI, CABP

Abstract

Antibiotic resistance became a global cause for failure of antimicrobial therapy nowadays. Cephalosporin being the class of drugs with broad spectrum of activity and favourable safety profile, many generations of this class nowadays used in clinical practice. The classification from first to fourth generation cephalosporin contain drugs which are effective against gram positive and gram negative organisms. This review describes about the fifth generation of cephalosporin, a new group of drugs in this class which are highly effective against pseudomonas and multidrug resistant staphylococcus aureus. They are less susceptible to development of resistance by microorganisms. The two drugs included in this group are Ceftaboprole and Ceftarolone. The spectrum, mechanisms of action, pharmacokinetics, dosage, drug interactions and clinical uses of these two drugs are described. The fifth generation cephalosporins are an ideal solution for antibiotic resistance in present era.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2017-02-28

Issue

Volume 3, Issue 1, January-February-2017

Section

Research Articles

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How to Cite

[1]
Nisha A. R., Vanishree H., Mahesh D. M., " Fifth generation cephalosporins: Drugs to overcome antibiotic resistance, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 1, pp.228-232, January-February-2017.