Assessment of Transforming Growth Factor β1 and DNA Cell Cycle in Egyptian Patients with Chronic Hepatitis-C Virus and Hepatocellular Carcinoma

Authors(4) :-Zahran Faten, El- Emshaty Hoda, Gouida Mona, Hussien Mohamed

Hepatocellular carcinoma (HCC) is the end-stage of chronic liver diseases (CLDs). The main aetiologies of CLDs are chronic hepatitis C virus (HCV) infection. The aim of this work was to evaluate diagnostic value of TGF-β1 in patients with chronic liver disease (CLD) Fibrosis, HCC and healthy individuals. The present study included 51 patients with Fibrosis (F2-F4), 30 Hepatocellular Carcinoma (HCC) patients, in addition 40 normal healthy individuals were enrolled in this study as control group. AFP and CEA were estimated in all groups. TGF-β1 and DNA Cell Cycle were estimated using Flow Cytometry technique. Results from this study revealed that there was high significance difference in APRI ratio, FIB-4 ratio between HCC, Fibrosis comparing with Control group (p<0.05), also there was high prevalence TGF-β1 in HCC patients comparing with both Fibrosis and healthy control group (P<0.005). In our study G2/M phase DNA Cell cycle was increased significantly in both HCC and Fibrosis patients. Based on our observation in this study TGF-β1 has diagnostic value importance in assessment of hepatocellular carcinoma.

Authors and Affiliations

Zahran Faten
Department of Chemistry, Zagazig University, Egypt
El- Emshaty Hoda
Gastroenterology Center, Mansoura University, Egypt
Gouida Mona
Mansoura Children Hospital, Mansoura University, Egypt
Hussien Mohamed
Mansoura Chest Hospital, Egypt

Hepatocellular Carcinoma (HCC), Transforming growth Factor beta1 TGF-β1, Alpha Feto Protein (AFP), Carcinoembryonic Antigen (CEA)

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Publication Details

Published in : Volume 3 | Issue 2 | March-April 2017
Date of Publication : 2017-04-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 769-774
Manuscript Number : IJSRSET1732149
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Zahran Faten, El- Emshaty Hoda, Gouida Mona, Hussien Mohamed , " Assessment of Transforming Growth Factor β1 and DNA Cell Cycle in Egyptian Patients with Chronic Hepatitis-C Virus and Hepatocellular Carcinoma , International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 2, pp.769-774, March-April-2017.
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