Manuscript Number : IJSRSET1732149
Assessment of Transforming Growth Factor β1 and DNA Cell Cycle in Egyptian Patients with Chronic Hepatitis-C Virus and Hepatocellular Carcinoma
Authors(4) :-Zahran Faten, El- Emshaty Hoda, Gouida Mona, Hussien Mohamed
Hepatocellular carcinoma (HCC) is the end-stage of chronic liver diseases (CLDs). The main aetiologies of CLDs are chronic hepatitis C virus (HCV) infection. The aim of this work was to evaluate diagnostic value of TGF-β1 in patients with chronic liver disease (CLD) Fibrosis, HCC and healthy individuals. The present study included 51 patients with Fibrosis (F2-F4), 30 Hepatocellular Carcinoma (HCC) patients, in addition 40 normal healthy individuals were enrolled in this study as control group. AFP and CEA were estimated in all groups. TGF-β1 and DNA Cell Cycle were estimated using Flow Cytometry technique. Results from this study revealed that there was high significance difference in APRI ratio, FIB-4 ratio between HCC, Fibrosis comparing with Control group (p<0.05), also there was high prevalence TGF-β1 in HCC patients comparing with both Fibrosis and healthy control group (P<0.005). In our study G2/M phase DNA Cell cycle was increased significantly in both HCC and Fibrosis patients. Based on our observation in this study TGF-β1 has diagnostic value importance in assessment of hepatocellular carcinoma.
Zahran Faten
Hepatocellular Carcinoma (HCC), Transforming growth Factor beta1 TGF-β1, Alpha Feto Protein (AFP), Carcinoembryonic Antigen (CEA)
Publication Details
Published in :
Volume 3 | Issue 2 | March-April 2017 Article Preview
Department of Chemistry, Zagazig University, Egypt
El- Emshaty Hoda
Gastroenterology Center, Mansoura University, Egypt
Gouida Mona
Mansoura Children Hospital, Mansoura University, Egypt
Hussien Mohamed
Mansoura Chest Hospital, Egypt
Date of Publication :
2017-04-30
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) :
769-774
Manuscript Number :
IJSRSET1732149
Publisher : Technoscience Academy
Journal URL :
https://ijsrset.com/IJSRSET1732149