Comparative Docking Studies on Erlotinib (Synthetic drug) and Curcumin (Natural drug) Against the Lung Cancer (TCF21)

Authors(1) :-Dr. D. Sarasa

Lung cancer is the second leading cause of death worldwide. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. A number of undesired side effects sometimes occur during chemotherapy. There has been a vast growth in the field of herbal medicine and these drugs popularly are increasing both in developing and developed countries because of their natural origin, more therapeutic effect and less side effects. Since ancient cultures, tribal people methodically collected information on herbs and developed well-defined herbal drugs for the treatment of many diseases. Mostly, cancer patients are gaining benefit from treatment with herbal medicine. In the present study the anti cancer activity of the existing drug (Erlotinib) and natural compound Curcumin (Curcuma longa) were compared based on the protein ligand interactions were carried out using bioinformatics software and tools. Protein ligand interactions in the present investigation revealed that curcumin is more effective to bind the gene TCF21 comparatively erlotinib.

Authors and Affiliations

Dr. D. Sarasa
Assistant Professor, PG and Research department of Zoology, Quaid-e-millath government college for women, Chennai, Tamil Nadu, India

TCF21, Curcumin, Erlotinib, Autodock.

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Publication Details

Published in : Volume 3 | Issue 5 | July-August 2017
Date of Publication : 2017-08-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 521-527
Manuscript Number : IJSRSET1734116
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Dr. D. Sarasa, " Comparative Docking Studies on Erlotinib (Synthetic drug) and Curcumin (Natural drug) Against the Lung Cancer (TCF21), International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 5, pp.521-527, July-August-2017.
Journal URL : http://ijsrset.com/IJSRSET1734116

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