Water Mediated One Pot Synthesis of pyrazolo[1,5-a] Pyrimidine Derivatives and their Antimicrobial Activity

Authors(2) :-Dr. Jayesh Babariya, Dr. Yogesh T. Naliapara

In this paper we have described the water mediated synthesis of substituted triazolopyrimidine derivatives in moderate to good yield. The reaction of various substituted aldehydes with 1-(3,4-dimethoxyphenyl)-4,4,4-trifluorobutane-1,3-dione as active methylene compound and 5-amino-3-(methylthio)-1H-pyrazole-4-carbonitrile afforded the triazolo pyrimidine derivatives in the presence boric acid and water as a solvent. We have also optimized the reaction condition using the various solvent. We have confirmed the structure on the basis of spectroscopic technique. All the synthesized compounds were evaluated for their antimicrobial activity. The investigation of antimicrobial and antifungal screening data revealed that all the tested compounds showed moderate to significant activity.

Authors and Affiliations

Dr. Jayesh Babariya
Shree H.N.Shukla College of Science, Rajkot, Gujarat, India
Dr. Yogesh T. Naliapara
Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India

Pyrazolo[1,5-a]pyrimidine, Triazolo pyrimidine, Biological evaluation

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Publication Details

Published in : Volume 3 | Issue 6 | September-October 2017
Date of Publication : 2017-10-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 654-663
Manuscript Number : IJSRSET1736136
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Dr. Jayesh Babariya, Dr. Yogesh T. Naliapara, " Water Mediated One Pot Synthesis of pyrazolo[1,5-a] Pyrimidine Derivatives and their Antimicrobial Activity, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 6, pp.654-663, September-October-2017.
Journal URL : http://ijsrset.com/IJSRSET1736136

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