Serofrequency of Mumps Virus among Children with Type One Diabetes Mellitus Comparing to Control Group in Khartoum State

Authors(4) :-Abeya Salah Ibrahim, Wafa Ibrahim Elhag, Nasr Mohamed Nasr, Mohamed Hussein Arbab

Background and Objectives: Epidemiological studies suggested that Mumps pancreatitis may associated with subsequent development of type one diabetes mellitus (T1D). This study was aimed to detect sero frequency of Mumps virus among children with T1D mellitus comparing to control group in Khartoum state.
Methods: This was a descriptive case control study involve 90 children with T1D (Test group) and 90 healthy children (Control group) in Khartoum, patients aged between (1-5) years old, conducted in Omdurman Pediatric Teaching Hospital and Gaber Abo Eleiz Hospital - Khartoum State, Sudan, during February to September 2016. Mumps virus IgG for all participants was investigated using commercially available enzyme-linked immunosorbent assay (ELISA). Generated data were analyzed using SPSS and excel software programs.
Results: The results revealed that the frequency of Mumps IgG were 23 (25.6%) and 3 (3.3%) among patients and control group respectively, also shown statistically significant relationship between Mumps virus infection and T1D with P- value (0.048). 
Conclusion: The seropositivity of Mumps virus among children with type one diabetes mellitus is significantly detected, further workup is required to co relate and  confirmatory test and fellow up with large scale specimen is recommended.

Authors and Affiliations

Abeya Salah Ibrahim
aculty of Medical Laboratory Sciences, Al Neelain University, Sudan
Wafa Ibrahim Elhag
Associate professor, Faculty of Medical Laboratory Sciences, Microbiology Department, Al Neelain University, Sudan
Nasr Mohamed Nasr
Assistant professor, Omdurman Ahlia University, Microbiology Department, Sudan
Mohamed Hussein Arbab
Assistant professor of medical Microbiology Omdurman Ahlia University, Sudan

Anti Mumps, Type I diabetes mellitus.

  1. Mishra, B.; Pujhari, S. K.; Dhiman, V.; Mahalakshmi, P.; Bharadwaj, A.; Pokhrel, S, et al (2013). "Genotyping and subtyping of mumps virus isolates from the Indian subcontinent". Archives of Virology 158 (11): 2359-2363.
  2. CDC. Mumps-United States, 1985-1988. MMWR Morb Mortal Wkly Rep. 1989 Feb 24. 38(7):101-5.
  3. Watson JC, Hadler SC, Dykewicz CA, et al. Measles, mumps, and rubella-vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR - Morbidity & Mortality Weekly Report. 1998 May 22. 47(8):1-57.
  4. Ginsberg F, Witt ME, Fedun B, et al. Diabetes mellitus and autoimmunity in patients with the congenital rubella syndrome. Revue of Infectious Disease. 1985; 7 Suppl. 1:S170-S176.
  5. Notkins AL. On the track of viruses. Nature journal for Microbiology. 1984; 311(5983):209-210.
  6. Jenson AB, Rosenberg HS and Notkins AL. Pancreatic islet-cell damage in children with fatal viral infections. Lancet. 1980; 2(8190):354-358.
  7. Shimada A and Maruyama T. Encephalomyocarditis-virus-induced diabetes model resembles ‘fulminant’ Type 1 diabetes in humans. Diabetologia. 2004; 47(10):1854-1855.
  8. Ragi W, Makman wailse et al. Variation and trends in incidence of childhood diabetes in Europe. eurodiab ace Study Group. Lancet. 2000; 355(9207):873-876. 
  9. Hyoty H, Hiltunen M, Reunanen A, Leinikki P, Vesikari T, Lounamaa R, Tuomilehto J, Akerblom HK: Decline of mumps antibodies in type 1 (insulin-dependent) diabetic children and a plateau in the rising incidence of type 1 diabetes after introduction of the Mumps-measles-rubella vaccine in Finland: Childhood Diabetes in Finland Study Group. Diabetologia 36 :1303-1308,1993.
  10. Haller MJ, Atkinson MA and Schatz D. Type 1 diabetes mellitus: etiology, presentation, and management. Pediatric Clinician of North America. 2005; 52(6):1553-1578.
  11. Goto A, Takahashi Y, Kishimoto M, Nakajima Y, Nakanishi K, Kajio H and Noda M. 2008. Acase of fulminant type 1 diabetes diabetes associated with significant elevation of mumps titers. Endocrinology J 55: 561-564.

Publication Details

Published in : Volume 4 | Issue 1 | January-February 2018
Date of Publication : 2018-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 239-243
Manuscript Number : IJSRSET1736211
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Abeya Salah Ibrahim, Wafa Ibrahim Elhag, Nasr Mohamed Nasr, Mohamed Hussein Arbab, " Serofrequency of Mumps Virus among Children with Type One Diabetes Mellitus Comparing to Control Group in Khartoum State, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.239-243, January-February-2018.
Journal URL :

Article Preview