Synthesis and Anticancer Activity of new N-mustard Substituted Coumarin Derivatives

Authors(5) :-Nirav Tatamiya, Jayesh babariya, Jaydeep Rajpara, Yogesh T. Naliapara, D. M. Purohit

A series of N-mustard Substituted- coumarin have been synthesized characterized and evaluated for their in vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-Cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-3-nitro-2H-chromen-2-one derivatives. Among these compounds screened, three compounds (NT-2g, NT-2f and NT-2e) showed GI50 range from 80 to 95 g/ml. All synthesized compounds were characterized by IR, NMR and mass spectral analysis and screened for Anticanceractivity using PC-3 cell line. All the compounds showed moderate to good anticancer activity.

Authors and Affiliations

Nirav Tatamiya
Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
Jayesh babariya
Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
Jaydeep Rajpara
Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
Yogesh T. Naliapara
Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
D. M. Purohit
Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India

4-chloro,3-nitro coumarin; aniline mustard; anticancer activity

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Publication Details

Published in : Volume 3 | Issue 6 | September-October 2017
Date of Publication : 2017-10-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 45-51
Manuscript Number : IJSRSET17368
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Nirav Tatamiya, Jayesh babariya, Jaydeep Rajpara, Yogesh T. Naliapara, D. M. Purohit, " Synthesis and Anticancer Activity of new N-mustard Substituted Coumarin Derivatives, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 6, pp.45-51, September-October.2017
URL : http://ijsrset.com/IJSRSET17368

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