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Synthesis and Anticancer Activity of new N-mustard Substituted Coumarin Derivatives

Authors(5):

Nirav Tatamiya, Jayesh babariya, Jaydeep Rajpara, Yogesh T. Naliapara, D. M. Purohit
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A series of N-mustard Substituted- coumarin have been synthesized characterized and evaluated for their in vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-Cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-3-nitro-2H-chromen-2-one derivatives. Among these compounds screened, three compounds (NT-2g, NT-2f and NT-2e) showed GI50 range from 80 to 95 g/ml. All synthesized compounds were characterized by IR, NMR and mass spectral analysis and screened for Anticanceractivity using PC-3 cell line. All the compounds showed moderate to good anticancer activity.

Nirav Tatamiya, Jayesh babariya, Jaydeep Rajpara, Yogesh T. Naliapara, D. M. Purohit

4-chloro,3-nitro coumarin; aniline mustard; anticancer activity

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Publication Details

Published in : Volume 3 | Issue 6 | September-October - 2017
Date of Publication Print ISSN Online ISSN
2017-10-31 2395-1990 2394-4099
Page(s) Manuscript Number   Publisher
45-51 IJSRSET17368   Technoscience Academy

Cite This Article

Nirav Tatamiya, Jayesh babariya, Jaydeep Rajpara, Yogesh T. Naliapara, D. M. Purohit, "Synthesis and Anticancer Activity of new N-mustard Substituted Coumarin Derivatives", International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 6, pp.45-51, September-October-2017.
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