Design, Synthesis and Biological Screening of Pyrazolo [3,4-b] Pyridines Containing Quinoline-4-One

Authors(3) :-Pankajkumar Singala, Pratik Talpara, V. H. Shah

We would like to report herein synthesis of two new pyrazolo[3,4-b]pyridines. Furthermore the characterization of product is carried out by elemental analysis and spectral analysis. Products were evaluated for their in vitro biological assay for antimicrobial activity against various bacterial standard strains i.e. S. pyogenes MTCC-442, S. aureus MTCC-96, E. coli MTCC-443, and B. subtilis MTCC-441 and antifungal activity against Aspergillus niger MTCC-282 and Candida albicans MTCC-227 at different concentrations, results were compared with standard drugs.

Authors and Affiliations

Pankajkumar Singala
Department of Chemistry, Saurshtra University, Rajkot, Gujarat, India
Pratik Talpara
Department of Chemistry, Saurshtra University, Rajkot, Gujarat, India
V. H. Shah
Department of Chemistry, Saurshtra University, Rajkot, Gujarat, India

Heterocycles, Synthesis, Reflux, Spectroscopy, Antimicrobial Activity

  1. El-borai, M. A.; Rizk, H. F.; Abd-Aal, M. F.; El-Deeb, I. Y. Eur. J. Med. Chem. 2012, 48, 92.
  2. Parekh, N. M.; Maheria, K. C. Med. Chem. Res.2012, 21, 4168.
  3. Godaa, F. E.; Abdel-Aziz, Alaa A.-M.; Attef, O. A. Bioorg. Med. Chem.2004, 12, 1845.
  4. Andreas, S.; Andrij, D. Curr. Org. Chem. 2011, 15, 1423.
  5. Diana, P.; Carbone, A.; Barraja, P.; Martorana, A.; Gia, O.; DallaVia, L.; Cirrincione, G. Bioorg. Med. Chem. Lett. 2007, 17, 6134.
  6. Wei, F.; Zhao, B.-X.; Huang, B.; Zhang, L.; Sun, C.-H.; Dong, W. L.; Shin, D. S., Miao J.-Y. Bioorg. Med. Chem. Lett.2006, 16, 6342.
  7. Abdel-Aziz, H. A.; Saleh, T. S.; El-Zahabi, H. S. A. Archiv der Pharmazie 2010, 343, 24.
  8. Stepanenko, I. N.; Novak, M. S.; Mühlgassner, G.; Roller, A.; Hejl, M.; Arion, V. B.; Jakupec, M. A.; Keppler, B. K. Inorg. Chem. 2011, 50, 11715.
  9. Misra, R. N.; Xiao, H.; Rawlins, D. B.; Shan, W.; Kellar, K. A.; Mulheron, J. G.; Sack, J. S.; Tokarski, J. S.; Kimbally, D.; Webster, K. R. Bioorg. Med. Chem. Lett., 2003, 13, 2405.
  10. Witherington, J.; Bordas, V.; Gaiba, A.; Garton, N. S.; Naylor, A.; Rawlings, A. D.; Slingsby, B. P.; Smith, D. G.; Takle, A. K.; Ward, R. W. Bioorg. Med. Chem. Lett., 2003, 13, 3055.
  11. Akahane, A.; Kuroda, S.; Itani, I.; Tabuchi, S.; Sato, Y.; Matsuoka, N.; Tada, M.; Matsuoka, H.; Oku, T.; Tanaka, A. (Fujisawa Pharmaceutical Co., Ltd Japan) A. PCT Int. Appl. (2001), 69 pp. Al20010607; Chem. Abstr., 135,33489a (2001).
  12. Akahane, A.; Tanaka, A.; (Fujisawa Pharmaceutical Co., LtdJapan) A. PCT W: JP, Chem. Abstr., 138,24732a (2003).
  13. Takabe, F.; Shibayama, A.; Yamaguchi. M.; Yamaji, M.; Hanai, R.; Sadohara, H. JpnKokaiTokkyoKoho JP 09 59 276 (1997); Chem. Abstr., 126,277477a (1997).
  14. El-Emary, T. I.; El-Dean Kamal, A. M.; El-Kashef, H. S. Farmaco. 1998, 53,383.
  15. El-Kashef, H. S.; El-Emary, T. I.; Gasquet, M.; Timon-David, P.; Maldonado, J.; Vanelle, P. Pharmazie., 2000, 55, 572.
  16. El-Emary, T. I. J. Chinese Chem. Soc., 2007, 54, 507.
  17. National Committee for Clinical and Laboratory Standards, Method for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Approved Standard, fourth ed. NCCLS, Villanova, Italy, 1997, Document M 100-S7. S100-S157.
  18. D.H. Isenberg, Essential Procedure for Clinical Microbiology, American Society for Microbiology, Washington, (1998).
  19. Zgoda, J. R.; Porter, J. R. Pharm. Biol. 2001, 39, 22

Publication Details

Published in : Volume 3 | Issue 8 | November-December 2017
Date of Publication : 2017-12-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 864-867
Manuscript Number : IJSRSET1738228
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Pankajkumar Singala, Pratik Talpara, V. H. Shah, " Design, Synthesis and Biological Screening of Pyrazolo [3,4-b] Pyridines Containing Quinoline-4-One, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 8, pp.864-867, November-December-2017.
Journal URL : http://ijsrset.com/IJSRSET1738228

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