Synthesis of new 1,2,4-Triazole derivatives and their Antimicrobial Screening

Authors

  • Pankajkumar Singala  Department of Chemistry, Saurshtra University, Rajkot, Gujarat, India
  • Pratik Talpara  Department of Chemistry, Saurshtra University, Rajkot, Gujarat, India

Keywords:

Triazole, methylation, N-butylation, Suzuki-Miyaura coupling, solvent, spectroscopy

Abstract

Present work illustrates synthesis and biological evaluation of substituted 1,2,4 trizole derivatives. Synthesis carried out by condensation reaction of benzothiamide derivative with 2,2,2-trifluoroacetohydrazide to give 1,2,4-triazole, which further modified by N-alkylation and Suzuki miyaura coupling reaction. Furthermore, the characterization of product is carried out by elemental analysis and spectral analysis. Products were evaluated for their in vitro biological assay for antibacterial activity against various bacterial standard strains i.e. S. pyogenes MTCC-442, S. aureus MTCC-96, E. coli MTCC-443, and B. subtilis MTCC-441 and antifungal activity against Aspergillus niger MTCC-282 and Candida albicans MTCC-227 at different concentrations, results were compared with standard drugs.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2017-12-31

Issue

Volume 3, Issue 8, November-December-2017

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Pankajkumar Singala, Pratik Talpara, " Synthesis of new 1,2,4-Triazole derivatives and their Antimicrobial Screening, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 8, pp.1009-1012, November-December-2017.