Efficient Synthesis of Novel Therapeutic Agent Possessing Sulfonamide Oxothiazolidine Moiety

Authors

  • Prof. (Dr.) S. Gaur  Coordination and Bioinorganic Lab, Department of Chemistry, J. N. V. University, Jodhpur Rajasthan, India
  • Neelam Jatolia   Coordination and Bioinorganic Lab, Department of Chemistry, J. N. V. University, Jodhpur Rajasthan, India

Keywords:

Oxothiazolidine - Sulfonamide Moieties, Therapeutic Agent (Anticonvulsant).

Abstract

A convenient method of synthesizing sulphonamide compounds possessing oxothiazolidine moiety is described, which has been carried out in excellent isolated yields. The physicochemical characterization was unambiguously confirmed by the usual spectroscopic methods. 1HNMR, 13CNMR, IR and the microbial screening revealed excellent positive effects.

References

  1. Kim S.J., Jung M.H., Yoo K.H., Cho J.H. and C.H Oh. Bioorg.Med. Chem.Lett., 18, 5815(2008).
  2. Gregorg W.A., Brittelli D.R., Wang C.L.J., Wuonola M.A., Mcripley R.J., Eustice D.C., Elberly V.S. and Slee A.M., J .Med.Chem., 32, 1673(1989).
  3. Hideaki K., Masayuki M., Hiroyki K., Tetsu-i-chiro M., Kimiko K. and Hiroyuki O., J Org.Chem., 64,1052(1999).
  4. Wouters J., Curr. Med.Chem., 5, 137(1998).
  5. Gottschlich C. and Ruecker H., Biorg. Med. Chem. Lett., 2, 165(1992).
  6. Jarreau F.X, Koening J.J. and Rovei V., Chem Abstr., 116 , 188072r (1992).
  7. Brittelli D.R., Eustine D.C., Batholomew D.T., Slee A.M., Feldmann P.A, Braun L.J. and Borkowspi J.J., Drugs Exp. Chim. Res., 16,149(1990).
  8. Albright J.D. and Sun S.W., Chem Abstr., 118, 2553346(1993).
  9. Georg W. and Okel D.M.G., Inorg. Chem Acta., 82, 101(1984).
  10. Asadi M. and Khah M.S., J. Iran.Chem.Soc., 7(4), 875(2010).
  11. Singh B.K., Bhojak N. and Anant P., E.Jou. of Chem., 9(2), 532 (2012).
  12. Jen H., Cho J. and Oh C.H., Eur.J.Med. Chem., 42, 358(2007).
  13. Ford C.W., Jurenko G.E. and Barbachyn M.R., Curr. Drug, Targ. Infect. Dis., 1, 181(2001).
  14. Kim S.J., Jung M.H., Yoo K.H., Cho J.H. and Oh C.H., Biorg. Med. Chem. 8, 5815(2008).
  15. Aryane S., Sultana N., Haroon U. and Mesaik M.A., Bioinorg. Chem. App. 2009, 914105(2009).
  16. Kamal A., Swapna P., Shetti V.C.R.N.C.R., Shaik V., Rao M.P.N. and Gupta S., Eur. J. Med. Chem.,62, 661(2013).
  17. Berredjem M., Bouchareb F., Kaki S.A., Dekhil M. and Aoub N.E., Arab. J.Chem.Dio. Org., 101016j (2013).
  18. Bouchareb X., Boufas W., Cheloufi H. and Berredjem M ., Relat. Elem.,189, 587(2014).
  19. Kostava I.P., Manolov I.L. and Rudolova M.K., Acta Pharm., 52, 37(2014).
  20. Gunniran K.O., Ajanku K.O., James O.O., Ajane O.O., Adekoya J.A. and Nwinyi O.C., African Journ. Of Pune & App. Chem. 2(7), 69(2008).
  21. Hongxia P., Shenning L., Yoxi S., Xinato W. and Wenxin D., Cryst. Res. Technol., 41(4), 423(2006).
  22. Bouzina A., Grib I., Bechlem K., Belhani B., Aoub N.E. and Berredjem M., Kalbala Int. Journal of modern SC, 2 ,98(2016).
  23. Vogel. Job P., Ann . Chim., 11, 979(1936).
  24. S.E.Turner and Anderson, J Amer Chem Soc., 71, 912(1994).
  25. Dubey R.C. and Maheshwari D.K, Practical Microbiology, S.Chand & Company Ltd., 172(2002).
  26. Kumar B.K., Ravinder, Swamy G.B. and Swang S.J., Indian J Chem. 33A, 136(1994).
  27. Dwiredi Rashmi and Dhakrey Rajesh, J.Ind. Council Chem., 23(2) 56(2003).
  28. Aswar A.S., Bansod A.D. and Mahale R.G., J.Ind. Council Chem. 23(2), 10(2006).
  29. Dholakiya P.P. and Patel M.N., J.Ind. Council Chem, 20(2), 21(2013).
  30. Hania M.M., E-Journal of Chemistry , 6SI, 5508(2009).
  31. S.Gaur, M.Ranka and R.Purohit, J.Ind. Council Chem., 24(2),51(2007).
  32. Gaur S., Ranka M. and Purohit R., Int. Chem. Sci., 6(4), 2189(2008).
  33. Gaur S.,Joshi K., J.Ind. Council Chem., 29(1&2), 55(2012).

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Published

2018-02-28

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Section

Research Articles

How to Cite

[1]
Prof. (Dr.) S. Gaur, Neelam Jatolia , " Efficient Synthesis of Novel Therapeutic Agent Possessing Sulfonamide Oxothiazolidine Moiety, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.158-162 , January-February-2018.