Synthesis and Biological Evaluation of Some Diverse Dyhdropyrimidine Dervatives

Authors(1) :-Amish P. Khamar

A novel series of dihydropyrimidine derivatives were synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. Two compounds, ethyl 4-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 4a and ethyl 4-[3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 4d were found to be the most active compounds in vitro with MIC of 0.02 µg/mL against MTB and were 18 times more potent than isoniazid.

Authors and Affiliations

Amish P. Khamar
Arts, Science & R. A. Patel Commerce College, Bhadran, Gujarat, India

Dihydropyrimidines, Antitubercular Activity, Antimycobacterial Activity.

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Publication Details

Published in : Volume 1 | Issue 1 | January-Febuary 2015
Date of Publication : 2015-02-27
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 415-419
Manuscript Number : IJSRSET184104
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Amish P. Khamar, " Synthesis and Biological Evaluation of Some Diverse Dyhdropyrimidine Dervatives, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 1, pp.415-419, January-Febuary-2015.
Journal URL : http://ijsrset.com/IJSRSET184104

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