Synthesis of Pyrimidine, Pyran and Pyridine Derivatives and their Biological Evaluation and Molecular Docking Studies as Potential CDK-1 and GSK-3 Inhibitors

Authors(1) :-Dipak C. Patel

Thirty five new compounds belonging to pyrimidine, pyran and pyridine classes were synthesized and tested against two protein kinases, CDK-1/cyclin B and GSK-3.  Among these compounds, 2-amino-4-(2-butyl-5-chloro-4H-imidazol-4-yl)-6-(4-hydroxyphenyl)pyridine-3-carbonitrile 17d was identified as the most potent inhibitor of these kinases. To identify possible binding modes, docking of the most active compounds into the active sites of CDK-1/cyclin B and GSK-3 was carried out.  The molecular modeling studies brought to the fore stereochemistry and nature of the central core ring as major determinants affecting CDK-1/cyclin B and GSK-3 activity.

Authors and Affiliations

Dipak C. Patel
The H. N. S. B. Ltd. Science College, Himmatnagar, Gujarat, India

CDK-1, GSK-3, Molecular Docking

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Publication Details

Published in : Volume 1 | Issue 1 | 2014
Date of Publication : 2018-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 155-163
Manuscript Number : IJSRSET184105
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Dipak C. Patel, " Synthesis of Pyrimidine, Pyran and Pyridine Derivatives and their Biological Evaluation and Molecular Docking Studies as Potential CDK-1 and GSK-3 Inhibitors, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 1, pp.155-163, -2014.
Journal URL : http://ijsrset.com/IJSRSET184105

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