Synthesis of Several Dihydropyrimidines as Antimycobacterial Agents

Authors

  • Nirul V. Gothi  Arts, Science & R. A. Patel commerce college, Bhadran, Gujarat, India

Keywords:

Dihydropyrimidines; Antimycobacterial activity; MDR-TB.

Abstract

A small series of 30 dihydropyrimidine compounds were synthesized and assessed for their in vitro antimycobacterial potential against Mycobacterium tuberculosis H37Rv. The lowest MIC value, 0.02 µg/mL, was found for compounds 4a and 4d. Both the compounds showed comparatively low cytotoxicity, and were potent against M. tuberculosis strains resilient to known drugs.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2015-02-27

Issue

Volume 1, Issue 1, January-February-2015

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Nirul V. Gothi, " Synthesis of Several Dihydropyrimidines as Antimycobacterial Agents, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 1, pp.410-414, January-February-2015.