Synthesis of Several Dihydropyrimidines as Antimycobacterial Agents

Authors(1) :-Nirul V. Gothi

A small series of 30 dihydropyrimidine compounds were synthesized and assessed for their in vitro antimycobacterial potential against Mycobacterium tuberculosis H37Rv. The lowest MIC value, 0.02 g/mL, was found for compounds 4a and 4d. Both the compounds showed comparatively low cytotoxicity, and were potent against M. tuberculosis strains resilient to known drugs.

Authors and Affiliations

Nirul V. Gothi
Arts, Science & R. A. Patel commerce college, Bhadran, Gujarat, India

Dihydropyrimidines; Antimycobacterial activity; MDR-TB.

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Publication Details

Published in : Volume 1 | Issue 1 | January-Febuary 2015
Date of Publication : 2015-02-27
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 410-414
Manuscript Number : IJSRSET184106
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Nirul V. Gothi, " Synthesis of Several Dihydropyrimidines as Antimycobacterial Agents, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 1, pp.410-414, January-Febuary-2015.
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