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An Efficient Protocol for Acid-Amine Coupling using T3P as Coupling Agent

Authors(4):

Arpit C. Radadia, Jaydip G. Rajpara, Rajendra Jadav, Yogesh T. Naliapara
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Amide bond is prevalent in peptides. Moreover, at least 25% pharmaceutical products also contain amide bond. Acid amine coupling of 4-(4-aminophenyl)morpholin-2-one with different acids has been synthesized in presence of T3P (Propylphosphonic anhydride), DIPEA base with Ethyl acetate as a solvent at room temperature for 30 mins to yield N-(4-(2-oxomorpholino)phenyl)-2-phenylquinoline-4-carboxamide derivatives.

Arpit C. Radadia, Jaydip G. Rajpara, Rajendra Jadav, Yogesh T. Naliapara

Acid-Amine Coupling, T3P (Propylphosphonic Anhydride), Quinolone 4 Carboxylic Acid

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Publication Details

Published in : Volume 4 | Issue 1 | January-February - 2018
Date of Publication Print ISSN Online ISSN
2018-02-28 2395-1990 2394-4099
Page(s) Manuscript Number   Publisher
84-87 IJSRSET184110   Technoscience Academy

Cite This Article

Arpit C. Radadia, Jaydip G. Rajpara, Rajendra Jadav, Yogesh T. Naliapara, "An Efficient Protocol for Acid-Amine Coupling using T3P as Coupling Agent ", International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.84-87, January-February-2018.
URL : http://ijsrset.com/IJSRSET184110.php

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