An Efficient Protocol for Acid-Amine Coupling using T3P as Coupling Agent

Authors(4) :-Arpit C. Radadia, Jaydip G. Rajpara, Rajendra Jadav, Yogesh T. Naliapara

Amide bond is prevalent in peptides. Moreover, at least 25% pharmaceutical products also contain amide bond. Acid amine coupling of 4-(4-aminophenyl)morpholin-2-one with different acids has been synthesized in presence of T3P (Propylphosphonic anhydride), DIPEA base with Ethyl acetate as a solvent at room temperature for 30 mins to yield N-(4-(2-oxomorpholino)phenyl)-2-phenylquinoline-4-carboxamide derivatives.

Authors and Affiliations

Arpit C. Radadia
Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
Jaydip G. Rajpara

Rajendra Jadav

Yogesh T. Naliapara

Acid-Amine Coupling, T3P (Propylphosphonic Anhydride), Quinolone 4 Carboxylic Acid

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Publication Details

Published in : Volume 4 | Issue 1 | January-February 2018
Date of Publication : 2018-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 84-87
Manuscript Number : IJSRSET184110
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Arpit C. Radadia, Jaydip G. Rajpara, Rajendra Jadav, Yogesh T. Naliapara, " An Efficient Protocol for Acid-Amine Coupling using T3P as Coupling Agent , International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.84-87, January-February-2018.
Journal URL : http://ijsrset.com/IJSRSET184110

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