Synthesis and Antimicrobial Activity of Some Newer Derivative of Pyrimidine

Authors(1) :-Dr. Deepshikha

Some New Bioactive heterocyclic compounds were synthesize among them pyrimidine compounds were found to possess important pharmacological and antimicrobial properties. Pyrimidine and to chromenes have structural and biological activities relationship so halogenated chromeno pyrimidine were synthesis where structure were characterized by NMR, IR, UB,GC-MS and elemental analysis. They were screened for antimicrobial activity. The Fluoro and methyl Heterocyclic showed highest biological activity.

Authors and Affiliations

Dr. Deepshikha
M.Sc.(IIT ROORKEE), B.Ed., M.Phill(IIT ROORKEE), Ph.D., Assistant Professor, Department of Chemistry, M. M. College Modinagar, Ghaziabad, Uttar Pradesh, India

Chromene, Pyramidines, Antibacterial, Antifungal, Synthesis, Novel Drugs

  1. R. Kharb, M. Tyagi and A. K. Sharma, "Current status and future scenario of pyrimidine derivatives having antimicrobial potentia," Der Pharma Chem., vol. 6, no. 4, pp. 298–320, 2014.
  2. R. D. Murray, J. Mendez, and S. A. Brown, The Natural Coumarins: Occurrence, Chemistry and Biochemistry, vol.9 Hoboken, New Jersey, United States: John Wiley & Sons, 1982.
  3. M. A. Al-Haiza, M. S. Mostafa, and M. Y. El-Kady, "Synthesis and Biological Evaluation of Some New Coumarin Derivatives," Molecules, vol. 8, no. 2, pp. 275–286, Feb. 2003.
  4. M. A. Bhat, N. Siddiqui, S. A. Khan, and M. I. Mohamed, "Synthesis of triazolothiazolidinone derivatives of coumarin with antimicrobial activity," Acta Pol Pharm, vol. 66, no. 6, pp. 625–632, 2009.
  5. W. A. El-Sayed, M. M. M. Ramiz, and A. A.-H. Abdel-Rahman, "Anti-Hepatitis B Virus Activity of New N4 -?-D-Glycoside Pyrazolo[3,4-d]pyrimidine Derivatives," Publ. J. Nat. Res.,vol.21, pp. 323–328, 2009.
  6. M. S. Mustafa, M. M. El-Abadelah, M. A. Zihlif, R. G. Naffa, and M. S. Mubarak, "Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners," Molecules, vol. 16, no. 12, pp. 4305–4317, May 2011.
  7. P. Thompson and L. Webel, Antimalarial agents: chemistry and pharmacology. vol.6,New York: Academic Press, 1972.
  8. E. McChesney and C. Fitch, "4-Aminoquinolines," in Antimalarial drugs II. Current antimalarials and new drug developments, W. Peters and W. Richards, Eds. Berlin, vol.31,1984, pp. 3–60.
  9. S. Bhatia and M. Gupta, "1, 3, 4-Oxadiazole as antimicrobial agents: An overview," J. Chem. Pharm. Res., vol. 3, no. 3, pp. 137–147, 2011.
  10. A. Choudhury, H. Chen, C. N. Nilsen, and K. L. Sorgi, "A chemoselective aniline–chloropyrimidine coupling in a competing electrophilic environment," Tetrahedron Lett., vol. 49, no. 1, pp. 102–105, Jan. 2008.
  11. M. D. M. H. Bhuiyan, K. M. D. M. Rahman, M. D. K. Hossain, A. Rahim, M. I. Hossain, and M. Abu Naser, "Synthesis and antimicrobial evaluation of some new thienopyrimidine derivatives.," Acta Pharm., vol. 56, no. 4, pp. 441–50, 2006.
  12. M. R. Prasad, J. Prashanth, K. Shilpa, and D. P. Kishore, "Synthesis and Antibacterial Activity of Some Novel Triazolothienopyrimidines.," ChemInform, vol. 38, no. 40, Oct. 2007.
  13. H. M. Aly, N. M. Saleh, and H. a. Elhady, "Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents," Eur. J. Med. Chem., vol. 46, no. 9, pp. 4566–4572, 2011.
  14. B. V. Ashalatha, B. Narayana, K. K. V. Raj, and N. Kumari, "Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydrof 11benzothknol 2,3-d 1pyrimi¬din-4(3H)-one derivatives," Eur. J. Med. Chem, vol. 42, pp. 719–728, 2007.
  15. T. George, C. Kaul, R. S. Gmwal, and R. Tahilramani, "Antihypertensive and mono-amine oxidase inhibitory activity of some derivatives of 3-formy1-4-oxo-4H¬pyrido11,2-alpyrimidine," J. Med. Chem, vol. 14, pp. 913–915, 1971.
  16. O. Bruno, C. Brullo, A. Ranise, S. Schenone, F. Bondavalli, E. Barocelli, V. Ballabeni, M. Chiavarini, M. Tognolini, and M. Impicciatore, "Synthesis and pharmacological evaluation of 2,5-cycloamino-5H-[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity," Bioorg Med Chem Lett, vol. 11, no. 11, pp. 1397–1400, 2001.
  17. R. K. Russell, J. B. Press, R. a. Rampulla, J. J. McNally, R. Falotico, J. a. Keiser, D. a. Bright, and A. Tobia, "Thiophene systems. 9. Thienopyrimidinedione derivatives as potential antihypertensive agents," J. Med. Chem., vol. 31, no. 9, pp. 1786–1793, 1988.
  18. H. Liu, H.-Q. Wang, and Z.-J. Liu, "Synthesis and herbicidal activity of novel pyrazolo[3,4-d]pyrimidin-4-one derivatives containing aryloxyphenoxypropionate moieties.," Bioorg. Med. Chem. Lett., vol. 17, no. 8, pp. 2203–2209, 2007.
  19. J.-M. Wang, T. Asami, S. Yoshida, and N. Murofushi, "Biological Evaluation of 5-Substituted Pyrimidine Derivatives as Inhibitors of Brassinosteroid Biosynthesis," Biosci. Biotechnol. Biochem., vol. 65, no. 4, pp. 817–822, Jan. 2001.
  20. P. Acosta, B. Insuasty, A. Ortiz, R. Abonia, M. Sortino, S. A. Zacchino, and J. Quiroga, "Solvent-free microwave-assisted synthesis of novel pyrazolo[4?,3?:5,6]pyrido[2,3-d]pyrimidines with potential antifungal activity," volume 18.Arab. J. Chem., Mar. 2015.
  21. M. Mamaghani, F. Shirini, E. Bassereh, and R. Hossein Nia, "1,2-Dimethyl-N-butanesulfonic acid imidazolium hydrogen sulfate as efficient ionic liquid catalyst in the synthesis of indeno fused pyrido[2,3-d]pyrimidines," J. Saudi Chem. Soc., vol. 42, pp. 1–7, Dec. 2014.
  22. M. Ghashang, S. S. Mansoor, and K. Aswin, "Pentafluorophenylammonium triflate (PFPAT) catalyzed facile construction of substituted chromeno[2,3-d]pyrimidinone derivatives and their antimicrobial activity," J. Adv. Res., vol. 5, no. 2, pp. 209–218, Mar. 2014.
  23. Y. Kotaiah, K. Nagaraju, N. Harikrishna, C. Venkata Rao, L. Yamini, and M. Vijjulatha, "Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines," Eur. J. Med. Chem., vol. 75, pp. 195–202, Mar. 2014.
  24. amanian, and G. Gopikrishna, "One pot synthesis of fused chromeno-pyrano-pyrimidines and evaluation of their antimicrobial activity," Indian J. Chem., vol. 53B, no. 03, pp. 345–351, 2014.
  25. H. M. Aly and N. M. Saleh, "Utility of a pyrimidine thione derivative in the synthesis of new fused pyrimido[4,5d]pyrimidine, pyrido[2,3-d]pyrimidine and different types of thienopyrimidine derivatives," Int. J. Adv. Res., vol. 2, no. 4, pp. 694–702, 2014.
  26. R. B. Patil and S. D. Sawant, "Synthesis, Docking Studies and Evaluation of Antimicrobial and in Vitro Antiproliferative Activity of 5h-Chromeno 4,3-D Pyrimidin-2-Amine Derivatives," Int. J. Pharm. Pharm. Sci., vol. 7, no. 2, pp. 304–308, 2015.
  27. C. Xu, G. Yang, C. Wang, S. Fan, L. Xie, and Y. Gao, "An Efficient Solvent-Free Synthesis of 2-Hydroxy-2-(trifluoromethyl)-2H-chromenes Using Silica-Immobilized L-Proline," Molecules, vol. 18, no. 10, pp. 11964–11977, Sep. 2013.
  28. G. C. Ramaprasad, B. Kalluraya, B. S. Kumar, and S. Mallaya, "Synthesis, antibacterial and antifungal activities of some novel 1,3,4-oxadiazole analogues," Int. J. Pharm. Pharm. Sci., vol. 4, no. 4, pp. 210–213, 2012.
  29. V. K. Sahu, A. K. Singh, and D. Yadav, "Review article on 1, 3, 4-Oxadiazole derivaties and it’s Pharmacological activities," Int. J. ChemTech Res., vol. 3, no. 3, pp. 1362–1372, 2011.
  30. S. Sharma, P. K. Sharma, N. Kumar, and R. Dudhe, "Chemistry and pharmacological potentials of Oxadiazoles: A Review," Der Pharma Chem., vol. 2, no. 4, pp. 253–263, 2010.

Publication Details

Published in : Volume 4 | Issue 1 | January-February 2018
Date of Publication : 2018-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 478-488
Manuscript Number : IJSRSET1841109
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Dr. Deepshikha, " Synthesis and Antimicrobial Activity of Some Newer Derivative of Pyrimidine, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.478-488, January-February.2018

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