Synthesis and Biological Activity of Some Newer Heterocycles

Authors

  • Dr. Neelam Baliyan  M.Sc., Ph.D., Assistant Professor, Department of Chemistry Sahu Jain P.G. College, Najibabad, Distt-Bijnor, Uttar Pradesh, India

Keywords:

Chromeno Oxadiazoles. Oxadizole Chromanooxadizole, Antimicrobial.

Abstract

Oxadiazoles are an important class of heterocyclic compounds that are known to possess important pharmacological and antimicrobial properties. chromenes are also known to possess antimicrobial properties. 1, 3, 4-chromeno oxadiazoles, 6-chloro-3- (5-phenyl-1,3,4-oxadiazol-2-yl)-2-(trifluoromethyl)-2H-chromen-2-ol and its derivatives containing synthesis and characterise by spectroscopy. The synthesized compounds were screened for antimicrobial activity found prominent antimicrobial is not.

References

  1. Bachwani M. and Sharma V., Antimicrobial activities of 1,3,4-oxadiazoles: A review IJRAP,2011, 2(6), 1738 -1742
  2. Sanmati K. J. and Jyotsana N., Synthesis and biological evaluation of 3,5-disubstituted-1,2,4-oxadiazoles as anti-histaminic agents. World Journal of Pharmacy and PharmaceuticalSciences, 2014, Volume 3, Issue 7, 762-773.
  3. Mohamed S. M., and Said H. K., Studies on the synthesis and antimicrobial activity of 2-oxo-2H-chromene-3- carbohydrazide derivatives. Der Pharma Chemica, 2014, 6(3):312-319
  4. Sudha B.N., Sridhar C., Sastry V.G., Sreevidya O., Lavanya S., Jyothi V.A., Nagesh V., Sen S.,Chakraborty R., Synthesis, Characterisation and anti-helmintic activity of 3-(4-acetyl-5-phenyl-4,5-dihydro-1,3-4-oxadiazol-2yl)-2H-chromen-2-one derivatives. Indian Journal of Chemistry,2013, 52B, 422-427.
  5. Bhatiya S., and Gupta M., 1, 3, 4-Oxadiazole as antimicrobial agents: An overview. J. Chem.Pharm. Res., 2011, 3(3):137-147
  6. Ramaprasad G.C., Kalluraya B., Kumar B.S., Mallaya S., Synthesis, antibacterial and antifungalactivities of some novel 1,3,4-oxadiazole analogues. International Journal of Pharmacy andPharmaceutical Sciences, 2012, 4(4), 210-213.
  7. Sahu V.K.R., Singh A.K., YadavD., Review article on 1, 3, 4-Oxadiazole derivaties and it’sPharmacological activities.International Journal of ChemTech Research, 2011, Vol. 3, No.3,1362-1372.
  8. Sharma S., Sharma P. K., Kumar N, Dudhe R., A Review: Oxadiazole Their Chemistry andPharmacological Potentials. Der Pharma Chemica, 2010, 2(4): 253-263.
  9. Ohmoto, K., Yamamoto, T., Horiuchi, T., Imanishi, H., Odagaki, Y., Kawabata, K., Sekioka, T.,Hirota, Y., Matsuoka, S., Nakai, H., Toda, M., Cheronis, J. C., Spruce, L. W., Gyorkos, A.,Wieczorek, M.,"Design and synthesis of new orally active nonpeptidic inhibitors of humanneutrophil elastase" J. Med. Chem. 2000, 43, 4927-4929.
  10. Synthesis, characterization of some novel chromeno oxidazole derivativeshttp://shodhganga.inflibnet.ac.in/bitstream/10603/8559/8/08_chapter-3.pdf
  11. Saini M.S., Manhas V.S., Dwivedi J. Pharmacological Importance of 1, 3, 4-Oxadiazole and its Derivatives: A Review. WJPRT, 2013, Vol. 1(2)
  12. Kharb R., Kaur R., Sharma A.K. Vistas on antimicrobial potential of novel oxadiazolederivatives in modern medicinal chemistry. European Journal of Biomedical and PharmaceuticalSciences. 2014, 1(2), 401-420.
  13. Singh R., Chauhan A. Biological Importance of 1, 3, 4-Oxadiazole derivatives. I.J.A.B.R, 2013,VOL. 3(2), 140-14.
  14. Gilani S.J., ZZaman M.T., Nagarajan K., Goel R., Arora A. Progress in pharmacologicalpotential of oxadiazoles: A review. International Bulletin of Drug Research., 2(1): 132-146
  15. Othman A.A., Kihel M., Amara S. 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazolederivatives as potential antibacterial agentsArabian Journal of Chemistry (2014, in press).
  16. Gingolani, G., Gaultrieri, F., Pigini, M. "Notes. Researches in the Field of AntiviralCompounds. Mannich Bases of 3-Hydroxycoumarin" J. Med. Chem. 1969, 12, 531-532.
  17. El-Naggar, A. M., Ahmed, F. S. M., Abd El-Salam, A. M., Radi, M. A., Latif, M. S. A."Synthesis and biological activity of some new 3-and 6-substituted coumarin amino acidderivatives. Part I" J. Heterocycl. Chem. 1981, 18, 1203-1207.
  18. Synthesis, characterization of some new 5H- chromeno [2,3-d] pyrimidine derivatives.http://shodhganga.inflibnet.ac.in/bitstream/10603/8559/7/07_chapter-2.pdf
  19. Xu C., Yang G., Wang C., Fan S., Xie L., and Gao Y. An Efficient Solvent-Free Synthesis of 2-Hydroxy-2-(trifluoromethyl)-2H-chromenes Using Silica-Immobilized L-Proline. Molecules2013, 18, 11964-11977

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Published

2018-02-28

Issue

Section

Research Articles

How to Cite

[1]
Dr. Neelam Baliyan, " Synthesis and Biological Activity of Some Newer Heterocycles, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.489-495, January-February-2018.