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Microamount of Pd(II) Catalyzed Oxidation of Nuroleptic Drug (Gabapentin) by Potassium Bromated (KBrO3) in Perchloric (HCIO4) Acid Medium : A Kinetic Study

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Reena Patel, Shailesh Kumar, Abhishek Verma, Sheila Srivastava
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Here we investigated the kinetics of Pd(II) catalyzed oxidation of gabapentin by potassium bromate in acidic medium and in temperature range 30-450C. Potassium bromate shows excellent oxidant properties and first order kinetics is observed with respect to it. Oxidation rate is also found to be first order with respect to catalyst, Pd(II).The reaction is carried out in the presence of mercuric acetate as a scavenger for chloride ion. The experimental results show first order kinetics with respect to the catalyst Pd(II)] while zero order with respect to substrate, i.e., gabapentin was observed. The reaction shows negligible effect of [Hg(OAc)2], and ionic strength of the medium. [H+] and Chloride ion positively influence the rate of reaction. The reaction between potassium bromate and gabapentin in acid medium shows 1:2 stoichiometry. To calculate activation parameters, the reactions have been studied at four different temperatures between 30 to 45ºC. A mechanism involving the complex formation between catalyst and oxidant has been proposed. [1-carboxy cyclohexane1-acetic acid] acid has been identified chromatographically and spectroscopically as the final product of oxidation of gabapentin. Based on the kinetic data, reaction stoichiometry and product analysis, a reaction mechanism has been proposed and rate law has been derived

Reena Patel, Shailesh Kumar, Abhishek Verma, Sheila Srivastava

Kinetics, Potassium Bromated , Gabapentin, Pd(II)

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Publication Details

Published in : Volume 4 | Issue 1 | January-February - 2018
Date of Publication Print ISSN Online ISSN
2018-02-28 2395-1990 2394-4099
Page(s) Manuscript Number   Publisher
207-214 IJSRSET184123   Technoscience Academy

Cite This Article

Reena Patel, Shailesh Kumar, Abhishek Verma, Sheila Srivastava, "Microamount of Pd(II) Catalyzed Oxidation of Nuroleptic Drug (Gabapentin) by Potassium Bromated (KBrO3) in Perchloric (HCIO4) Acid Medium : A Kinetic Study", International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.207-214, January-February-2018.
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