Synthesis of Some Novel Tetrazole Derivatives & Evaluation of Their Biological Activity

Authors

  • Dhas A. K.  Department of chemistry, Deogiri College, Aurangabad, Maharashtra, India
  • Shirsat A. J.  Department of chemistry, R. B. Attal Arts, Commerce & Science College, Georai, Beed, Maharashtra, India
  • Rupnar B. D.  Department of chemistry, Arts, Commerce & Science College, Kille- Dharur, Beed, Maharashtra, India
  • Bhagat S. S.  
  • Kakade G. K.  

Keywords:

Tetrazole, Azide, Antimicrobial Activity.

Abstract

High efficient process for the preparation of novel tetrazole derivatives has been developed from aryl nitrile and sodium azide through [3+2] cycloaddition reaction. This method has the advantage of high yield and easy work up process.

References

  1. T. S. Lin, W. H. Prusoff, J. Med. Chem. 1978, 21, 109-112.
  2. Zablocky, J. A.; Miyano, M.; Sashidhar, N. R.; Panzer-Knodle, S.; Nicholson, N.;
  3. Feigen, L. J. Med. Chem. 1992, 35, 4914-4917.
  4. B. Das, C. R. Reddy, D. N. Kumar, M. Krishnaiah, R. Narender, Synlett, 2010, 391-394.
  5. Kumar, A.; Narayanan, R.; Shechter, H. J. Org. Chem. 1996, 61, 4462-4465.
  6. Sreedhar, B.; Kumar, A. S.; Yada, D. Tetrahedron Lett. 2011, 3565-3569.
  7. Mohite P.B., Bhaskar V.H. International Journal of Pharm Tech Research Vol.3, No.3,pp 1557-1566,
  8. Lang, L.; Li, B.; Liu, W.; Jiang, L.; Xu, Z.; Yin, G. Chem. Commun. 2010, 448-450.

International Journal of Scientific Research in Science, Engineering and Technology

Downloads

Published

2018-01-22

Issue

Volume 4, Issue 3, January-February-2018

Section

Research Articles

License

Copyright (c) IJSRSET

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Dhas A. K., Shirsat A. J., Rupnar B. D., Bhagat S. S., Kakade G. K., " Synthesis of Some Novel Tetrazole Derivatives & Evaluation of Their Biological Activity, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 3, pp.07-09, January-February-2018.