Studies on Mangenese (II), Cobalt(II), Nickel(II), Copper(II) and Zn(II) complexes of substituted phenyl-thiazolyl-thiosemicarbazide

Authors

  • N. G. Kolhe  Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India
  • J. K. Khedkar  Department of Chemistry, New Arts, Commerce and Science College, Shevgaon, Maharashtra, India
  • Y. H. Deshpande  aDepartment of Chemistry, Dr. Babasaheb Ambedkar Marathwada University

Keywords:

Thiazolyl Thiosemicarbazide, Metal Ions, Metal-Ligand Complexes, Stability, Thermodynamics

Abstract

Thiazolyl thiosemicarbazide consists of a thiazole moiety in the structure. The compounds belonging to the thiazole ring systems have shown considerable activity in various fields including medicinal chemistry. Vitamin B1, sulphatiazole, promizole, nitridazole, aminitrazole, and thiabendazole, all contain thiazole ring in one form or other. Thiosemicarbazide containing –NCS group are known to possess pronounced biological activities. Thiosemicarbazide along with thiosemicarbazones have been used in various life saving drugs and drug action of these compounds was found to have been increased when administered in the form of their metal complexes. However a survey of literature reveals that no work has been done with substituted thiazolyl thiosemicarbazides. In the present work we investigate the complex formation process between some substituted thiazolyl thiosemicarbazides synthesised in our laboratory for the first time and various metal ions belonging to transition and inner transition series. The stability of different complexes follows the order: Mn < Co < Ni < Cu > Zn.

References

  1. Pandey, V. K. and Agarwal A. K. Acta Cienc Indica Chem 1980, 6, 166
  2. Srivastava, U.; Pathak, R. B.; Bahel, B. C. J. Indian Chem Soc 1981,58, 822
  3. Dogmagk, G;. Behnisch, R.; Mietzsch, F.; Schmidt, H., Naturwissenschaflen, 1946, 33, 315
  4. El-Khair, A.; Mostafa, B.; Kamel, Kh. M.; Abdel-Hamid, I. A. Indian J. Chem 1977, 1010
  5. Orlova, N. N.; Akasevova, V. A.; Seliolovkin, D. A.; Bogdanova, N. B.; Pershin, G. N. Russ. Pharm. Toxicol, 1968, 348
  6. Crim, J.A.; Petering, H. G. Cancer Rev 1967, 27, 1278
  7. Bauer, D. J. ; Vincent, L. S.; Kempe, C. H.; Downie, A. W. Lancent, 1969, 20, 494
  8. Dwyer, F. P.; Mathew, E.; Roe, E.M.F.; Shulman, A. Br. J. Cancer , 1965, 19, 195
  9. Mashima, M. Bull. Chem. Soc. Jpn. 1964, 37, 974
  10. Pradhan, B. and Ramana Rao, D. V. J. Indian Chem. Soc. 1977, 54, 136
  11. Flaschka, H. R. "EDTA Titrations" Pergamon press, New York (1959)
  12. Vogel, A. I. "A Text Book of Practical Organic Chemistry" 3rd ed; Longmans London, 1959, p177
  13. Ahluwalia, V. K.; Dutta, U.; Sharma, H. R. Indian J. Chem. 1987, 26B, 88
  14. Van Uitert, Le-G. G.; Fernelius, W. C.; Douglas, B. E. J. Am. Chem. Soc. 1953, 75, 2736-2738
  15. Dasgupta, H. C. And Singh, V. V. Pd. J. Indian Chem. Soc. 1979, 954
  16. Lee, T. S.; Kolthoff, I. M.; Lessing, D. L. J. Am. Chem. Soc. 1948, 70, 2348
  17. Tanford, C.; Wagner, M. L. J. Am. Chem. Soc. 1953, 75, 434
  18. Basak. A.K.and Banerjee, D. J. Indian Chem. 1978, 55, 853
  19. Irving, H. M. and Rossoti, H. S. J. Chem. Soc. 1954, 2904-2910,
  20. Irving, H. M. and Williams, R. J. P. Nature, 1948, 162, 746
  21. Mali B. D. PhD thesis, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad.

International Journal of Scientific Research in Science, Engineering and Technology

Downloads

Published

2018-01-22

Issue

Volume 4, Issue 3, January-February-2018

Section

Research Articles

License

Copyright (c) IJSRSET

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
N. G. Kolhe, J. K. Khedkar, Y. H. Deshpande, " Studies on Mangenese (II), Cobalt(II), Nickel(II), Copper(II) and Zn(II) complexes of substituted phenyl-thiazolyl-thiosemicarbazide, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 3, pp.54-57, January-February-2018.