Synthesis, Characterization and Antimicrobial Activity of Some New Pyrazoline Derivatives of 3-Aryl-2-Isobutanoyl-N-Phenyl-Acrylamide

Authors

  • D. N. Joshi  Department of Chemistry, R. R. Mehta College of Science & C. L.Parikh College of commerce Palanpur Gujarat, India

Keywords:

3-Aryl-2-isobutanoyl-N-phenyl-acrylamide, Pyrazoles, Antimicrobial Activities.

Abstract

Some new 5-Aryl-3-isopropyl-4-[N-phenyl-aminocarbonyl]-4,5-dihydro-1H-pyrazoles.The pyrazoline derivatives of Type (1a-j) have been synthesized by the reaction of 3-Aryl-2-isobutanoyl-N-phenyl-acrylamide with hydrazine hydrate. All the prepared compounds were characterized by their spectral (I.R., N.M.R., Mass) data and screened for their antimicrobial activities.

References

  1. El-Maphraby M. A., Khalafalla A. K., Hassan M. E., Soleiman H. A.; J Indian Chem Soc 63, 910 (1986).
  2. Krapcho J., Turk C.; J Med Chem 22, 207 (1979).
  3. Raiford C. C., Tanzer C. K.; J Org Chem 6, 799 (1941).
  4. Hukki J., Laitinen P., Alberty J.; E. Pharm. Acta Helv. 43, 704 (1968).
  5. Jung J. C., Watkins E. B., Avery M. A.; Heterocycles 65, 77 (2005).
  6. Bansal E., Srivastava V. K., Kumar A.; Eur. J. Med.Chem. 36, 81 (2001).
  7. Udupi R. H., Rao S. N., Bhat A. R.; Indian J. Heterocycl. Chem. 7, 217 (1998).
  8. Ahn J. H., Kim H. M., Jung S. H., Kang S. K., Kim K. R., Rhee S. D., Bioorg. Med. Chem. Lett. 14, 4461 (2004).
  9. Villhauer E. B., Brinkman J. A., Naderi C. B., Dunning B. E., Mangold B. L.; J. Med. Chem. 45, 2362 (2002).
  10. Amr A. E.; Indian J. Heterocycl. Chem. , 10, 49 (2000).
  11. Hammam A. G., Fahmy A. F. M., Amr A. E., Mohamed A. M.; Indian J. Chem., 42 1985 (2003).
  12. Hammam A. G., Abdel Hafez N. A., Midura W. H.,Mikolajczyk M. Z.; Naturforsch., 55b, 417 (2000).
  13. Kumar A.; Indian J Chem 35A, 1018.(1996).
  14. Elguero J.; In Comprehensive Heterocyclic Chemistry, eds., A. R. Katritzky and C. W. res., Vol 5, Ch. 404.
  15. Theobald R. S.;Rodd’s Chemistry of Carbon Compounds, Ed. M. F. Ansell, Vol. IV, Part C, Ch. 16 2nd Edition, (Elsevier Science Publishers B.V. Amsterdam) 59 (1998).
  16. A L. Barry; The antimicrobial susceptibility test: Principle and practices, edited by llluslea & Febiger , (Philadelphia), USA, 180; Biol. Abstr., 1977, 64, 25183
  17. Panda J. Srinivas S. V., Rao M. E.; J. Indian Chem. Soc., 79(9), 770-1 (2002); Chem. Abstr., 138, 153499n (2003).

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Published

2018-08-30

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Section

Research Articles

How to Cite

[1]
D. N. Joshi, " Synthesis, Characterization and Antimicrobial Activity of Some New Pyrazoline Derivatives of 3-Aryl-2-Isobutanoyl-N-Phenyl-Acrylamide, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 1, pp.164-168, -2014.