Synthesis, Characterization and Antimicrobial Activity of Some New Pyrazoline Derivatives of 3-Aryl-2-Isobutanoyl-N-Phenyl-Acrylamide

Authors(1) :-D. N. Joshi

Some new 5-Aryl-3-isopropyl-4-[N-phenyl-aminocarbonyl]-4,5-dihydro-1H-pyrazoles.The pyrazoline derivatives of Type (1a-j) have been synthesized by the reaction of 3-Aryl-2-isobutanoyl-N-phenyl-acrylamide with hydrazine hydrate. All the prepared compounds were characterized by their spectral (I.R., N.M.R., Mass) data and screened for their antimicrobial activities.

Authors and Affiliations

D. N. Joshi
Department of Chemistry, R. R. Mehta College of Science & C. L.Parikh College of commerce Palanpur Gujarat, India

3-Aryl-2-isobutanoyl-N-phenyl-acrylamide, Pyrazoles, Antimicrobial Activities.

  1. El-Maphraby M. A., Khalafalla A. K., Hassan M. E., Soleiman H. A.; J Indian Chem Soc 63, 910 (1986).
  2. Krapcho J., Turk C.; J Med Chem 22, 207 (1979).
  3. Raiford C. C., Tanzer C. K.; J Org Chem 6, 799 (1941).
  4. Hukki J., Laitinen P., Alberty J.; E. Pharm. Acta Helv. 43, 704 (1968).
  5. Jung J. C., Watkins E. B., Avery M. A.; Heterocycles 65, 77 (2005).
  6. Bansal E., Srivastava V. K., Kumar A.; Eur. J. Med.Chem. 36, 81 (2001).
  7. Udupi R. H., Rao S. N., Bhat A. R.; Indian J. Heterocycl. Chem. 7, 217 (1998).
  8. Ahn J. H., Kim H. M., Jung S. H., Kang S. K., Kim K. R., Rhee S. D., Bioorg. Med. Chem. Lett. 14, 4461 (2004).
  9. Villhauer E. B., Brinkman J. A., Naderi C. B., Dunning B. E., Mangold B. L.; J. Med. Chem. 45, 2362 (2002).
  10. Amr A. E.; Indian J. Heterocycl. Chem. , 10, 49 (2000).
  11. Hammam A. G., Fahmy A. F. M., Amr A. E., Mohamed A. M.; Indian J. Chem., 42 1985 (2003).
  12. Hammam A. G., Abdel Hafez N. A., Midura W. H.,Mikolajczyk M. Z.; Naturforsch., 55b, 417 (2000).
  13. Kumar A.; Indian J Chem 35A, 1018.(1996).
  14. Elguero J.; In Comprehensive Heterocyclic Chemistry, eds., A. R. Katritzky and C. W. res., Vol 5, Ch. 404.
  15. Theobald R. S.;Rodd’s Chemistry of Carbon Compounds, Ed. M. F. Ansell, Vol. IV, Part C, Ch. 16 2nd Edition, (Elsevier Science Publishers B.V. Amsterdam) 59 (1998).
  16. A L. Barry; The antimicrobial susceptibility test: Principle and practices, edited by llluslea & Febiger , (Philadelphia), USA, 180; Biol. Abstr., 1977, 64, 25183
  17. Panda J. Srinivas S. V., Rao M. E.; J. Indian Chem. Soc., 79(9), 770-1 (2002); Chem. Abstr., 138, 153499n (2003).

Publication Details

Published in : Volume 1 | Issue 1 | 2014
Date of Publication : 2018-08-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 164-168
Manuscript Number : IJSRSET1849117
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

D. N. Joshi, " Synthesis, Characterization and Antimicrobial Activity of Some New Pyrazoline Derivatives of 3-Aryl-2-Isobutanoyl-N-Phenyl-Acrylamide, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 1, pp.164-168, .2014
URL : http://ijsrset.com/IJSRSET1849117

Follow Us

Contact Us