Comparative Network Pharmacology Based on Tanimoto Coefficient with Forbes-2 Coefficient

Authors(3) :-Basirun, Farit Mochammad Afendi, Wisnu Ananta Kusuma

Research on active compound contained in medicinal plant as ingredient for creating jamu has been widely practiced, but a detailed explanation of the mechanism of work in molecular and pharmacological still needs to be developed. In research of in silico, one of the common approaches done to look at the work mechanism of a compound was considering the similarity aspects of chemical structures between compounds. Measurement of similarity between compounds in general using Tanimoto coefficient. Based on the research result toward clustering 79 coefficient similarity to measure closseness of compounds, in addition Tanimoto, there was Forbes-2 coefficient found better similarity. Based on the statement the researcher was interested to do research with the aim of evaluating the Network Pharmacology medicinal plants that play the role of DM Type 2 by replacing Tanimoto coefficient with Forbes-2 coefficient. The evaluation method in this research used Mean Absolute Deviation (MAD). The result of the pharmacology network analysis using the Tanimoto coefficient was better compared to the Forbes-2 coefficient

Authors and Affiliations

Department of Statistics, Bogor Agricultural University, Bogor, Indonesia
Farit Mochammad Afendi
Department of Computer Science, Bogor Agricultural University, Bogor, Indonesia
Wisnu Ananta Kusuma
Tropical Biopharmaca Research Center Bogor Agriculture University, Bogor, Indonesia

DM Type 2, Jamu, Forbes-2 Coefficient, Tanimoto Coefficient, MAD

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Publication Details

Published in : Volume 4 | Issue 9 | July-August 2018
Date of Publication : 2018-07-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 348-355
Manuscript Number : IJSRSET184969
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Basirun, Farit Mochammad Afendi, Wisnu Ananta Kusuma, " Comparative Network Pharmacology Based on Tanimoto Coefficient with Forbes-2 Coefficient, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 9, pp.348-355, July-August-2018.
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