Manufacture and Determination of Absorbent in Bolus Radiotherapy Based On Alginate Using of 8 MeV and 10 MeV Energy

Authors(3) :-Hendra Tampubolon, Kerista Tarigan, Timbangen Sembiring

Bolus radiotherapy have been created by using material of mixture a silicone rubber as matrix and alginate powder as a filler through chemical solution deposition methods with variation of composition silicone rubber: alginate powder: catalyst (99 : 0 : 1)%wt, (80: 19: 1)%wt, (80: 18: 2)%wt, (80: 17: 3)%wt, (80:16: 4)%wt and (80: 15: 5)%wt. The sample fabrication was done in two steps. The first step of alginate powder is mixed with a solution of rubber and catalyst silicon until homogeneous for 5 minutes with the wet mixing method. The second step of the powder which was homogeneously mixed was printed with glass mould measuring 11 x 11 x 1 cm3 with variations in thickness of 5 mm, 10 mm and 15 mm then dried at 300. Each bolus sample is already to be characterized which includes: physical properties (density, porosity, and water absorption), mechanical properties (tensile strength, elongation and modulus young) and performance (CT Number and absorbency dose). The characterization results showed that alginate powder: optimum rubber silicon ie (80: 19) wt% at a thickness of 15 mm resulted in a density value of 2.091 x 103 kg/m3, porosity of 9.82% and water absorption of 1.66%. Mechanical properties with tensile strength 3.37 MPa, elongation at 45.28% and modulus of elasticity of 0.816 MPa. Bolus radiotherapy performance properties relative electron density (RED) values or CT numbers of 1.25 resulted in surface absorbance doses of 8 MeV of 101% and 10 MeV of 108.01%. The results of bolus radiotherapy based on composite alginate powder reinforced by silicone rubber can be applied as a cancer therapy material to replace bolus from wax, and paraffin.

Authors and Affiliations

Hendra Tampubolon
Department of Physics, University of Sumatera Utara, Medan, Sumatera Utara, Indonesia
Kerista Tarigan
Department of Physics, University of Sumatera Utara, Medan, Sumatera Utara, Indonesia
Timbangen Sembiring
Department of Physics, University of Sumatera Utara, Medan, Sumatera Utara, Indonesia

Alginate, Bolus, Radiotherapy Absorption Dosage, Silicone Rubber

  1. AAPM. (1991). “Clinical Electron-Beam Dosimetry: Reports of The AAPM Task Group No. 25”. American Association Physical in Medical
  2. Anusavice, Kenneth (2007), “Philips Science of Dental Material”, 11th Edition. Missouri: Elsevier.
  3. Barret A., Dobbs J., Morris S. & Roques T., (2009), “Practical Radiotherapy Planning”, 4th ed. UK Company, London.
  4. Blum, M. M., and John, H. 2011. Historical perspective and modern applications ofAttenuated Total Reflectance–Fourier Transform Infrared Spectroscopy (ATR-FTIR). Article in Drug Testing and Analysis. 4, 298-302.
  5. Campbell, I. M., 1988, Catalysis of Surfaces, Chapman and Hall, New York, 154.
  6. Charles M. Washington and Dennis Leaver, (2010), “Principles and Practice of Radiation Therapy”, Mosby
  7. FURIA, T.E. (Editor). 1972. “Handbook of food additives”.2nd edition. CRC Press Inc., USA. 653 pp.
  8. Gede W.J. & Heri S. (2017). “Fabrication and Characterization of Bolus Material Using Polydimethyl-Siloxane”, (January 2018), 015307. https://doi.org/10.1088/2053-1591/aaa447.
  9. Gunham B., Kemikler G., and Koca A. 2003. “Determination of Surface Dose and The Effect of Bolus To Surface Dose In Electron Beams”. Medical Dosimetry 28, pp. 193-198.
  10. Heri Sutanto, Eko H., Gede Wiratma J., Santi Yuli A., and Astri Suppa S. 2018. “Bolus Berbahan Silicone dan Natural Rubber”. Smart Medical Research Center, Universitas Diponegoro.
  11. Humpries S.M., Boyd K., Patricia C. and Francis D.N., 1996. “Comparison of Super Stuff and Paraffin Wax Bolus Therapy of Irreguler Surfaces”. Journal of Medical Dosimetry, 21, 155-157.
  12. Junaedi D., Setiawati E., Arifin Z. and ramantisa S., 2016. “Analisis Penggunaan Polydimethyl Siloxane Sebagai Bolus Dalam Radioterapi Menggunakan Elektron 8 MeV Pada Linac”. Youngster Physics Journal, 5, 391-398.
  13. Kang, E.T., Neoh, K.G. and Tan, K.L., 1998. Polyaniline: Polymer with ManyInterseting Intrinsic Redox State. Prog. Polym. Sci. Vol. 23, 277-324.
  14. Khan F.M. (2003), “The Physic of Radiation Therapy”, 3th ed. Lipincot Williams and Wilkins, Philadelphia, U.S.A.
  15. Khan F.M. (2014) , “The Physic of Radiation Therapy”, 5th ed. Lipincot Williams and Wilkins, Philadelphia, U.S.A.
  16. Khifitiyah M., Hidayanto E., dan Arifin Z, 2014. “Analisa Kurva Percentage Depth Dose (PDD) dan Profile Dose Untuk Lapangan Radiasi Simetri dan Asimetri Pada Linear Accelerator (LINAC) 6 dan 10 MV”. Youngster Physic Journal 3, pp. 279-286.
  17. KIRK and OTHMER. 1994. “Encyclopedia of chemical technology”. Fourth Edition. Volume 12. John Wiley & Sons, New York. 1091 pp.
  18. Metcalfe P., Kron T., and Hoban P. (2007). “The Physics of Radiotherapy X-Rays and Electrons”. Medical Physics Publishing.
  19. Muhammad A.I. and Ardyanata H., (2013). “Pengaruh Jenis Katalis Terhadap Kekuatan Tarik dan Stabilitas Termal Polidimetilsiloksan (PDMS) untuk Lapisan Pelindung Baja AISI 1050”, Jurnal Teknik Pomits, 2, 2337-3539.
  20. Nurhening Y., and Affandi A.N. 2012. “Tinjauan Sifat Hidrofobik Bahan Isolasi Silicone Rubber”. Teknik Elektro Universitas Negeri Yogyakarta.
  21. Nurmaulita. 2010. “Pengaruh Orietasi Serat Sabut Kelapa Dengan Resin Poliester Terhadap Karakteristik Papan Lembaran”. Tesis Magister Sains. Universitas Sumatera Utara : Medan
  22. Pam Cherry and Angela M, (2009). “Practical Radiotherapy Physic and Equipment”, Blackwell Publishing, U.S.A.
  23. Park, J.W. and Yea, J.W., 2015. “Three-Dimensional Customized Bolus for Intensity-Modulated Radiotherapy In aPatient With Kimura’s Disease Involving The Auricle”, Cancer/Radiotherapie 20, pp. 205-209.
  24. Podgorsak, E.B. (2005). “Radiation Oncology Physic: A Handbook for Teachers and Students”, International Atomic Energy Agency, Vienna, Austria.
  25. Segura T. and Burillo G., 2013. “Radiation Modification of Silicone Rubber With Glycidymethacrylate”, Radiation Physics and Chemistry 91, pp.101-107.
  26. Visscher S. and Barnett E., 2016. “Comparison of Bolus Materials to Highly Absorbent Polypropylene and Rayon Cloth”. Journal of Medical Imaging and Radiation Sciences, 1-6. doi: 10.1016/j.jmir.2016.08.003.
  27. Segura T. and Burillo G., 2013. “Radiation Modification of Silicone Rubber With Glycidymethacrylate”, Radiation Physics and Chemistry 91, pp.101-107.

Publication Details

Published in : Volume 6 | Issue 3 | May-June 2019
Date of Publication : 2019-06-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 123-131
Manuscript Number : IJSRSET196325
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Hendra Tampubolon, Kerista Tarigan, Timbangen Sembiring, " Manufacture and Determination of Absorbent in Bolus Radiotherapy Based On Alginate Using of 8 MeV and 10 MeV Energy, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 6, Issue 3, pp.123-131, May-June-2019. Available at doi : https://doi.org/10.32628/IJSRSET196325
Journal URL : http://ijsrset.com/IJSRSET196325

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