Facile Access to Polyfunctionalized Thiazolidinones and their Antimicrobial Evaluation

Authors(1) :-Nirali S. Mewada

Novel 4 - (4-cyanophenylamino) – 2 - (4-methylpiperazin-1-yl) – 5 - (5-(arylidene)-4-oxo-2-phenylthiazolidin-3-yl) benzoic acids were synthesized. The chemical structures of all the synthesized 4-Thiazolidinones were elucidated using IR, Mass and 1H NMR spectroscopy. The compounds were screened for their in vitro anti-microbial activity.

Authors and Affiliations

Nirali S. Mewada
Department of Chemistry, Government Science College, Gandhinagar, Gujarat, India

Polyfunctionalized, Thiazolidinones, Arylidene, Antimicrobial Activity

  1. A. K. Jain, A. V. Veerasamy, S. Kumar, R. A. Agrawal, Bioorg Med Chem. 11 (2012) 3378-3395.
  2. K.H. Chikhalia, M. J. Patel, J. Enzym Inhib. Med. Chem. 24 (2009) 960–966.
  3. A. Baliani, G. J. Bueno, M. l. Stewart,V. Yardley, R. Brun, M.P. Barrett, J. Med. Chem. 48 (2005) 5570–5579.
  4. M. Sergio, P. Davide, C. Paolo, B. Nicoletta, M. Diego, Chem. Med. Chem. 3 (2008) 873-876.
  5. D. H. Mahajan, C. Pannecouque, D. C. Erik, K. H. Chikhalia, Arch. Pharm. 342 (2009) 281–290.
  6. S. K. Srivastava, S. D. Srivastava, Ind. J. Chem. 38B (1999) 183-187.
  7. (a) A. K. Jain, A. V. Veerasamy, S. Kumar, R. A. Agrawal, Bioorg Med Chem. 11 (2012) 3378-3395.
  8. H. Oza, D. Joshi, H Parikh, Ind. J. Chem. 37B (1998) 822-825.
  9. G. Aridoss, G. Amirthaganesan, M.S. Kim, J.T. Kim, Y.T. Jeong, Eur. J. Med. Chem. 10 (2009) 4199-4210.
  10. S. Jaju, M. Palkar, V. Maddi, P.K. Ronad, S. Desai, D. Satyanarayana, M. Ghatole, Arch. Pharm. Chem. Life Sci. 324 (2009) 723-731
  11. N. S. Mewada, D. R. Shah, H. P. Lakum, K. H. Chikhalia Journal of the Association of Arab Universities for Basic and Applied Sciences, 20 (2016) 8-18.

Publication Details

Published in : Volume 3 | Issue 5 | July-August 2017
Date of Publication : 2017-08-15
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 757-761
Manuscript Number : IJSRSET196434
Publisher : Technoscience Academy

Print ISSN : 2395-1990, Online ISSN : 2394-4099

Cite This Article :

Nirali S. Mewada, " Facile Access to Polyfunctionalized Thiazolidinones and their Antimicrobial Evaluation, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 5, pp.757-761, July-August-2017. Citation Detection and Elimination     |     
Journal URL : https://ijsrset.com/IJSRSET196434

Article Preview