An Efficient Protocol for Acid-Amine Coupling using T3P as Coupling Agent

Authors

  • Arpit C. Radadia  Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Jaydip G. Rajpara  
  • Rajendra Jadav  
  • Yogesh T. Naliapara  

Keywords:

Acid-Amine Coupling, T3P (Propylphosphonic Anhydride), Quinolone 4 Carboxylic Acid

Abstract

Amide bond is prevalent in peptides. Moreover, at least 25% pharmaceutical products also contain amide bond. Acid amine coupling of 4-(4-aminophenyl)morpholin-2-one with different acids has been synthesized in presence of T3P (Propylphosphonic anhydride), DIPEA base with Ethyl acetate as a solvent at room temperature for 30 mins to yield N-(4-(2-oxomorpholino)phenyl)-2-phenylquinoline-4-carboxamide derivatives.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2018-02-28

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Volume 4, Issue 1, January-February-2018

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Research Articles

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[1]
Arpit C. Radadia, Jaydip G. Rajpara, Rajendra Jadav, Yogesh T. Naliapara "An Efficient Protocol for Acid-Amine Coupling using T3P as Coupling Agent " International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.84-87, January-February-2018.