Synthesis of Isobenzofuran Derivative {2, 6- Dichloro-4-[(Phenylthio) Methyl] Pyridine-3-Yl} (4-Methyl Phenyl) Methanol from 2, 6-Dichloro -4-[(Phenylthio) Methyl] Nicotinonitrite

Authors

  • Suchita B. Khamkar  Assistant Professor, Department of Chemistry, Balbhim Arts, Science and Commerce College, Beed, Maharashtra, India

Keywords:

Isobenzofuran, Diels- Alder reaction.

Abstract

The present work on the preparation of trapping of Furo [3,4-c] pyridine inspired us to studying the scope and limitations of this work. Beside this it was decided to work and study Tandem pummerer – Diels – Alder reaction on keto Sulphoxides with these keto Sulphoxides, we turned our attention to the formation of some azaligans via the standard sequential pummerer – Diels- Alder reaction. The treatment of keto -Sulphoxide with acetic anhydride, P-toluene sulphonic acid in presence of dimethyl maleate in refluxing toluene gave the bridged product.

References

  1. Padwa, A. Chem, Commun, 1998, 1417.
  2. For a review on heteroisobenzofurans, see : Basak, S.; Ghosh S. K.; Sarkar T.K. J. Indian Inst. Sci., 2001, 81, 431.
  3. Moskalev, N. V.; Gibble, G.W.; Tetrahedron Lett.2000, 43, 197.
  4. (a) Wiersum, U.E.; Eldred, C.D. Tetrahedron Lett. 1977, 1741. (b) Muller, P,; Schaller, J.-P. Tetrahedron Lett. 1989, 30, 1507.
  5. (a) Eberbach, W.; Fritz, H.; Laber, N.Angew. Chem. Int. Ed. Engl. 1988, 27, 568. (b) Eberbach, W,; Laber, N.; Business, J.; Fritz, H.; Ribs, G. Chem. Ber. 1993, 126, 975. (c) Business, J.; Keller, M.; Eberbach, W.Liebigs Ann. 1995, 1503.
  6. Gribble G.W.; Keavy, D.J.; Davis, D.A.; Saulneir, M.G.; Pelcman, B.; Barden, T.C.; Sibi, M.P.; Olson, E.R.; BelBruno, J.J.J.Org.Chem. 1992, 57, 5878.
  7. (a) Friedchrisen, W.; Schooning, A. Heterocycles 1986, 24, 307.

International Journal of Scientific Research in Science, Engineering and Technology

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Published

2021-07-25

Issue

Volume 9, Issue 5, July-August-2021

Section

Research Articles

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How to Cite

[1]
Suchita B. Khamkar, " Synthesis of Isobenzofuran Derivative {2, 6- Dichloro-4-[(Phenylthio) Methyl] Pyridine-3-Yl} (4-Methyl Phenyl) Methanol from 2, 6-Dichloro -4-[(Phenylthio) Methyl] Nicotinonitrite, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 9, Issue 5, pp.145-147, July-August-2021.