Synthesis, Characterization and Antimicrobial Studies of the Metal Complexes of β-Diketone

Authors

  • S. N. Sampal  Department of Chemistry, Kalikadevi Arts, Comm. and Science College, Shirur (ka), Beed, Maharashtra, India
  • P. B. Thombre  Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra India
  • V. S. Gavhane  Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra India
  • A. S. Rajbhoj  Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra India
  • S. T. Gaikwad  Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra India

Keywords:

Antimicrobial activity, Antioxidant, β-diketones, Metal-complexes, Magnetic susceptibility, TGA, XRD.

Abstract

The ligand 1-(2-bromo-5-methoxyphenyl)-3-(2-hydroxyphenyl) propane-1, 3-dione (L) and its transition metal complexes have been synthesized. The ligand synthesized using 2-hydroxy acetophenone and 2-bromo-5-methoxy benzoic acid. Each metal complex synthesized by metal nitrate with ?-diketone in the ratio 1:2 stiochimetry. The characteration were carried out by elemental analysis, UV-Visible spectroscopy, infrared spectroscopy,1H-NMR,13C-NMR, magnetic susceptibility, molar conductance, powder XRD and TGA for structural formulae study. The synthesized ?-diketones and their transition metal complexes have been screened for in vitro antibacterial, and antifungal activity using Resazurin 96 well plate method. This method is simple, sensitive, rapid, and reliable. It achieves more accurate minimum inhibitory concentration (MIC). The transition metal complexes and ligand showed moderate antimicrobial activity against all tested bacteria and fungi.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2021-07-25

Issue

Volume 9, Issue 5, July-August-2021

Section

Research Articles

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[1]
S. N. Sampal, P. B. Thombre, V. S. Gavhane, A. S. Rajbhoj, S. T. Gaikwad "Synthesis, Characterization and Antimicrobial Studies of the Metal Complexes of β-Diketone" International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 9, Issue 5, pp.161-167, July-August-2021.