Effect of Red, Yellow and White Light Emitting Diode (LED) on Rat's Retina

Authors

  • M. I. EL Gohary  Physics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
  • M.M. Gamal  Biophysics and Laser Science Unit, Research Institute of Ophthalmology, Giza, Egypt
  • A. E. Ibrahim  Biophysics and Laser Science Unit, Research Institute of Ophthalmology, Giza, Egypt
  • M. A. Abu Ghazala  Physics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt

Keywords:

Light Emitting Diodes, Electroretinogram

Abstract

Light-emitting diodes (LEDs) are the basic lighting components in screens of PCs, phones and TV sets; hence it is so important to know the implications of LED radiations on the human visual system. The present study is designed to evaluate the influence of Red, Yellow and White LEDs on rat's retina. Sixty-six female Wistar albino rats weighing 250-300 g classified into 4 groups. Group (1) served as control. Group (II) exposed to (645 nm) red LED (12 hr light - dark cycle) for 3, 7, 14 and 21days. Group (III) exposed to (588 nm) yellow LED (12 hr light - dark cycle) for 3, 7, 14 and 21days and Group IV exposed to (the wavelength peaks are 448.7 nm and 561 nm) white LED (12 hr light - dark cycle) for 3, 7, 14 and 21days. At the end of each period, electroretinogram (ERG) has been carried out. The results indicated that there was no significant effect for yellow LED on the ERG. After exposure of rat's retina to red and white LED, there is reduction in a- and b- wave amplitudes. The data suggest that the red and white LED may causes retinal toxicity. Therefore, it is very important to recognize the hazard of LED radiations that affects vision and take appropriate precautions for the eye safety.

References

  1. D M. Paskowitz, M. M. La Vail, and J. L. Duncan, 2006. "Light and inherited retinal degeneration". Br. J. Ophthalmol. Vol. 90, pp. 1060–1066, (2006).
  2. W K. Noell, V. S.Walker, , B. S. Kang, and S.Berman, 1966. "Retinal damage by light in rats". Invest. Ophthalmol. Vol. 5, 450–473, (1966).
  3. D T. Organisciak, R. A.Darrow, , L. Barsalou, , R. M. Darrow, and L.A. Lininger, , "Light-induced damage in the retina: differential effects of dimethyl thiourea on photoreceptor survival, apoptosis and DNA oxidation". Photochem. Photobiol. Vol. 70, pp. 261–268, (1999).
  4. C E. Reme, C. Grimm, F. Hafezi, A. Wenzel, and T. P. Williams, 2000 "Apoptos is in the retina: the silent death of vision". News Physiol. Sci. 15, pp. 120–124, (2000).
  5. CE. Reme, C. Grimm, F. Hafezi, A. Marti, and A. Wenzel, 1998. "Apoptotic cell death in retinal degenerations". Prog. Retin. Eye Res. Vol. 17, pp. 443–464, (1998).
  6. M Tanito, H. Masutani, H. Nakamura, A. Ohira, and J. Yodoi, 20002. "Cytoprotective effect of thioredoxin against retinal photic injury in mice". Invest. Ophthalmol. Vis. Sci. Vol. 43, pp. 1162–1167, (2002).
  7. RK. Kutty, G. Kutty, B. Wiggert, G.J. Chader, R.M. Darrow, and D.T. Organisciak, 1995. "Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethyl thiourea". Proc. Nat. Acad. Sci. USA, Vol. 92, pp. 1177–1181, (1995).
  8. A Ohira, M. Tanito, S. Kaidzu, and T. Kondo, 2003. "Glutathione peroxidase induced in rat retinas to counteract photic injury". Invest. Ophthalmol. Vis. Sci. Vol. 44, pp. 1230–1236, (2003).
  9. L Chen, T. Dentchev, R. Wong, P. Hahn, R. Wen, J. Bennett, and J.L. Dunaief, 2003. "Increased expression of ceruloplasmin in the retina following photic injury". Mol. Vis. Vol. 9, pp. 151–158, (2003).
  10. Z.Y. Li, M.O. Tso, H.M. Wang, and D.T. Organisciak, 1985. "Amelioration of photic injury in rat retina by ascorbic acid: a histopathologic study". Invest. Ophthalmol. Vis. Sci. Vol. 26, pp. 1589–1598, (1985).
  11. W.K. Noell, D.T. Organisciak, H. Ando, M.A. Braniecki, and C. Durlin, 1987. "Ascorbate and dietary protective mechanisms in retinal light damage of rats: electrophysiological, histological and DNA measurements". Prog. Clin. Biol. Res. 247, pp. 469–483, (1987).
  12. A. Dong, J. Shen, M.Krause, H. Akiyama, S.F. Hackett, H. Lai, and P.A. Campochiaro, 2006. "Superoxide dismutase 1 protects retinal cells from oxidative damage". J. Cell Physiol. Vol. 208, pp. 516 –526, (2006).
  13. F. Behar-Cohen, C. Martinsons, F. Vienot, G., Zissis, A., Barlier-Salsi, J. P., Cesarini, O., Enouf, M. Garcia, S. Picaud, and D. Attia, 2011. "Light-emitting diodes (LED)for domestic lighting: any risks for the eye?" Prog. Retin. Eye Res. Vol. 30, pp. 239–257, (2011).
  14. D.C. Holzman, 2010. "What’s in a color? The unique human health effect of blue light". Environ Health Perspect Vol. 118, pp. A22–A27, (2010).
  15. A. Spivey, 2011. "The mixed blessing of phosphor-based white LEDs". Environ Health Perspect Vol. 119, pp. A472–A473, (2011).
  16. J. Wu, S. Seregard and P.V. Algvere, 2006. "Photochemical damage of the retina". Surv Ophthalmol Vol. 51, pp. 461–481, (2006).
  17. F. Hafezi, A. Marti, K. Munz and C.E. Reme, 1997. "Light-induced apoptosis: differential timing in the retina and pigment epithelium". Exp Cell Res Vol. 64, pp. 963–970, (1997).
  18. D.T. Organisciak and D.K. Vaughan, 2010. "Retinal light damage: mechanisms and protection". Prog. Retin. Eye Res., Vol. 29, pp. 113-134. (2010).
  19. H. Terasaki, Y. Miyake, K. Mineo, and A. Tanikawa, 1997. "Focal macular electrorentinogram before and after drainage of macular dubretinal haemorrhage". American J. of ophth., Vol. 123, no.12, pp. 207-211, (1997).
  20. Y.M. Shang, G.S. Wang, D. Sliney, C.H. Yang, and L.L. Lee, 2014. "White light-emitting diodes (LEDs) at domestic lighting levels and retinal injury in a rat model". Environ. Health Perspect., Vol. 122, no.3, pp. 269-276, (2014).
  21. P. Youssef, N. Sheibani, and D. Albert, 2011. "Retinal light toxicity. Eye. Vol. 25, pp. 1-14, (2011).
  22. A. Dong, J. Shen, M. Krause, F. Hackett and P. Campochiaro, 2007. "Increased expression of glial cell line-derived neurotrophic factor protects against oxidative damage-induced retinal degeneration". Journal of Neurochemistry, Vol. 103, no. 3, pp. 1041-1052, (2007).
  23. L.Lu, , B. Oveson, Y. Jo, T. Lauer, S. Usui and K. Komeima, 2009. "Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage". Antioxid Redox Signal, Vol. 11. no. 4, pp. 715–724, (2009).
  24. H.Kolb, R. Nelson, E. Fernandez, and B. Jones, 2011. Web vision. "The organization of the retina and visual system". Copyright © web vision powered by word press. University of Utah Disclaimer Rhone, M.and A. Basu, 2008. Phytochemicals and age-related eye diseases. Nutr Rev., Vol. 66, no. 8, pp. 465-72, (2011).
  25. F. Vinberg, S. Strandman, and A. Koskelainen, 2009. "Origin of the fast-negative ERG component from isolated aspartate-treated mouse". Retina Journal of Vision, Vol. 9, no. 12, pp.1–17, (2009).

International Journal of Scientific Research in Science, Engineering and Technology

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Published

2017-08-30

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Volume 3, Issue 5, July-August-2017

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Research Articles

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[1]
M. I. EL Gohary, M.M. Gamal, A. E. Ibrahim, M. A. Abu Ghazala "Effect of Red, Yellow and White Light Emitting Diode (LED) on Rat's Retina" International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 5, pp.729-736, July-August-2017.