Water Mediated One Pot Synthesis of pyrazolo[1,5-a] Pyrimidine Derivatives and their Antimicrobial Activity
Keywords:
Pyrazolo[1,5-a]pyrimidine, Triazolo pyrimidine, Biological evaluationAbstract
In this paper we have described the water mediated synthesis of substituted triazolopyrimidine derivatives in moderate to good yield. The reaction of various substituted aldehydes with 1-(3,4-dimethoxyphenyl)-4,4,4-trifluorobutane-1,3-dione as active methylene compound and 5-amino-3-(methylthio)-1H-pyrazole-4-carbonitrile afforded the triazolo pyrimidine derivatives in the presence boric acid and water as a solvent. We have also optimized the reaction condition using the various solvent. We have confirmed the structure on the basis of spectroscopic technique. All the synthesized compounds were evaluated for their antimicrobial activity. The investigation of antimicrobial and antifungal screening data revealed that all the tested compounds showed moderate to significant activity.
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