Synthesis and Anticancer Activity of new N-mustard Substituted Coumarin Derivatives

Authors

  • Nirav Tatamiya  Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Jayesh babariya  Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Jaydeep Rajpara  Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Yogesh T. Naliapara  Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • D. M. Purohit  Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India

Keywords:

4-chloro,3-nitro coumarin; aniline mustard; anticancer activity

Abstract

A series of N-mustard Substituted- coumarin have been synthesized characterized and evaluated for their in vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-Cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-3-nitro-2H-chromen-2-one derivatives. Among these compounds screened, three compounds (NT-2g, NT-2f and NT-2e) showed GI50 range from 80 to 95 µg/ml. All synthesized compounds were characterized by IR, NMR and mass spectral analysis and screened for Anticanceractivity using PC-3 cell line. All the compounds showed moderate to good anticancer activity.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2017-10-31

Issue

Volume 3, Issue 6, September-October-2017

Section

Research Articles

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How to Cite

[1]
Nirav Tatamiya, Jayesh babariya, Jaydeep Rajpara, Yogesh T. Naliapara, D. M. Purohit "Synthesis and Anticancer Activity of new N-mustard Substituted Coumarin Derivatives" International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 6, pp.45-51, September-October-2017.