Plant Derived Phenolic Compounds as the Natural Antiglycating Agents

Authors

  • Parvaiz A. Dar  Department of Biochemistry, University of Kashmir, Jammu and Kashmir, India
  • Mohd Ishaq Dar  Cancer Pharmacology Division, IIIM, Jammu, Jammu and Kashmir, India
  • Sameer A Mir  
  • Mashooq A Dar  
  • Aarif Ali  
  • Masroor A. Padroo  
  • Sameer U. Khan  

Keywords:

Glycation, Polyphenols, Scavenging, AGEs,

Abstract

Glycation of biomolecules like proteins, nucleic acids and lipids involves non enzymatic addition of sugar and carbonyl compounds that results in formation of advanced glycation end products (AGEs). Accumulation of AGEs promote the progression of several diseases like diabetes, ageing and neurodegenerative disease. In order to prevent ageing and diabetic complications, there is a need to protect biomolecules from sugar induced glycation. Polyphenolic compounds possess significant in vitro anti-glycation activity. Polyphenols may inhibit the formation of AGEs either by scavenging ROS production during the glycation reaction or provides physical protection against glycating agents. The physical protection mechanism by polyphenols involves hydrogen bonding and non covalent interactions which acts as a sort of shield and prevents the accessibility of glycating agents on their target site. In this review, antiglycating activity of different polyphenolic compounds will be discussed.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2017-12-31

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Volume 3, Issue 8, November-December-2017

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Research Articles

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How to Cite

[1]
Parvaiz A. Dar, Mohd Ishaq Dar, Sameer A Mir, Mashooq A Dar, Aarif Ali, Masroor A. Padroo, Sameer U. Khan, " Plant Derived Phenolic Compounds as the Natural Antiglycating Agents, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 8, pp.674-677, November-December-2017.