Design, Synthesis and Biological Screening of Pyrazolo [3,4-b] Pyridines Containing Quinoline-4-One

Authors

  • Pankajkumar Singala  Department of Chemistry, Saurshtra University, Rajkot, Gujarat, India
  • Pratik Talpara  Department of Chemistry, Saurshtra University, Rajkot, Gujarat, India
  • V. H. Shah  Department of Chemistry, Saurshtra University, Rajkot, Gujarat, India

Keywords:

Heterocycles, Synthesis, Reflux, Spectroscopy, Antimicrobial Activity

Abstract

We would like to report herein synthesis of two new pyrazolo[3,4-b]pyridines. Furthermore the characterization of product is carried out by elemental analysis and spectral analysis. Products were evaluated for their in vitro biological assay for antimicrobial activity against various bacterial standard strains i.e. S. pyogenes MTCC-442, S. aureus MTCC-96, E. coli MTCC-443, and B. subtilis MTCC-441 and antifungal activity against Aspergillus niger MTCC-282 and Candida albicans MTCC-227 at different concentrations, results were compared with standard drugs.

References

  1. El-borai, M. A.; Rizk, H. F.; Abd-Aal, M. F.; El-Deeb, I. Y. Eur. J. Med. Chem. 2012, 48, 92.
  2. Parekh, N. M.; Maheria, K. C. Med. Chem. Res.2012, 21, 4168.
  3. Godaa, F. E.; Abdel-Aziz, Alaa A.-M.; Attef, O. A. Bioorg. Med. Chem.2004, 12, 1845.
  4. Andreas, S.; Andrij, D. Curr. Org. Chem. 2011, 15, 1423.
  5. Diana, P.; Carbone, A.; Barraja, P.; Martorana, A.; Gia, O.; DallaVia, L.; Cirrincione, G. Bioorg. Med. Chem. Lett. 2007, 17, 6134.
  6. Wei, F.; Zhao, B.-X.; Huang, B.; Zhang, L.; Sun, C.-H.; Dong, W. L.; Shin, D. S., Miao J.-Y. Bioorg. Med. Chem. Lett.2006, 16, 6342.
  7. Abdel-Aziz, H. A.; Saleh, T. S.; El-Zahabi, H. S. A. Archiv der Pharmazie 2010, 343, 24.
  8. Stepanenko, I. N.; Novak, M. S.; Mühlgassner, G.; Roller, A.; Hejl, M.; Arion, V. B.; Jakupec, M. A.; Keppler, B. K. Inorg. Chem. 2011, 50, 11715.
  9. Misra, R. N.; Xiao, H.; Rawlins, D. B.; Shan, W.; Kellar, K. A.; Mulheron, J. G.; Sack, J. S.; Tokarski, J. S.; Kimbally, D.; Webster, K. R. Bioorg. Med. Chem. Lett., 2003, 13, 2405.
  10. Witherington, J.; Bordas, V.; Gaiba, A.; Garton, N. S.; Naylor, A.; Rawlings, A. D.; Slingsby, B. P.; Smith, D. G.; Takle, A. K.; Ward, R. W. Bioorg. Med. Chem. Lett., 2003, 13, 3055.
  11. Akahane, A.; Kuroda, S.; Itani, I.; Tabuchi, S.; Sato, Y.; Matsuoka, N.; Tada, M.; Matsuoka, H.; Oku, T.; Tanaka, A. (Fujisawa Pharmaceutical Co., Ltd Japan) A. PCT Int. Appl. (2001), 69 pp. Al20010607; Chem. Abstr., 135,33489a (2001).
  12. Akahane, A.; Tanaka, A.; (Fujisawa Pharmaceutical Co., LtdJapan) A. PCT W: JP, Chem. Abstr., 138,24732a (2003).
  13. Takabe, F.; Shibayama, A.; Yamaguchi. M.; Yamaji, M.; Hanai, R.; Sadohara, H. JpnKokaiTokkyoKoho JP 09 59 276 (1997); Chem. Abstr., 126,277477a (1997).
  14. El-Emary, T. I.; El-Dean Kamal, A. M.; El-Kashef, H. S. Farmaco. 1998, 53,383.
  15. El-Kashef, H. S.; El-Emary, T. I.; Gasquet, M.; Timon-David, P.; Maldonado, J.; Vanelle, P. Pharmazie., 2000, 55, 572.
  16. El-Emary, T. I. J. Chinese Chem. Soc., 2007, 54, 507.
  17. National Committee for Clinical and Laboratory Standards, Method for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Approved Standard, fourth ed. NCCLS, Villanova, Italy, 1997, Document M 100-S7. S100-S157.
  18. D.H. Isenberg, Essential Procedure for Clinical Microbiology, American Society for Microbiology, Washington, (1998).
  19. Zgoda, J. R.; Porter, J. R. Pharm. Biol. 2001, 39, 22

International Journal of Scientific Research in Science, Engineering and Technology

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Published

2017-12-31

Issue

Volume 3, Issue 8, November-December-2017

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Research Articles

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How to Cite

[1]
Pankajkumar Singala, Pratik Talpara, V. H. Shah "Design, Synthesis and Biological Screening of Pyrazolo [3,4-b] Pyridines Containing Quinoline-4-One" International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 3, Issue 8, pp.864-867, November-December-2017.