Synthesis and Biological Evaluation of Some Diverse Dyhdropyrimidine Dervatives

Authors

  • Amish P. Khamar  Arts, Science & R. A. Patel Commerce College, Bhadran, Gujarat, India

Keywords:

Dihydropyrimidines, Antitubercular Activity, Antimycobacterial Activity.

Abstract

A novel series of dihydropyrimidine derivatives were synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. Two compounds, ethyl 4-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 4a and ethyl 4-[3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 4d were found to be the most active compounds in vitro with MIC of 0.02 µg/mL against MTB and were 18 times more potent than isoniazid.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2015-02-27

Issue

Volume 1, Issue 1, January-February-2015

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Amish P. Khamar "Synthesis and Biological Evaluation of Some Diverse Dyhdropyrimidine Dervatives" International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 1, Issue 1, pp.415-419, January-February-2015.