Microamount of Pd(II) Catalyzed Oxidation of Nuroleptic Drug (Gabapentin) by Potassium Bromated (KBrO3) in Perchloric (HCIO4) Acid Medium : A Kinetic Study

Authors

  • Reena Patel  Ph.D student, Department of Applied Chemistry B.B.A.U. Lucknow, Uttar Pradesh,India
  • Shailesh Kumar  Assistant Professor , Department of Applied Chemistry B.B.A.U. Lucknow, Uttar Pradesh,India
  • Abhishek Verma  Associate Professor, Department of Chemistry Feroze Gandhi College, Raebareli, Uttar Pradesh, India
  • Sheila Srivastava  

Keywords:

Kinetics, Potassium Bromated , Gabapentin, Pd(II)

Abstract

Here we investigated the kinetics of Pd(II) catalyzed oxidation of gabapentin by potassium bromate in acidic medium and in temperature range 30-450C. Potassium bromate shows excellent oxidant properties and first order kinetics is observed with respect to it. Oxidation rate is also found to be first order with respect to catalyst, Pd(II).The reaction is carried out in the presence of mercuric acetate as a scavenger for chloride ion. The experimental results show first order kinetics with respect to the catalyst Pd(II)] while zero order with respect to substrate, i.e., gabapentin was observed. The reaction shows negligible effect of [Hg(OAc)2], and ionic strength of the medium. [H+] and Chloride ion positively influence the rate of reaction. The reaction between potassium bromate and gabapentin in acid medium shows 1:2 stoichiometry. To calculate activation parameters, the reactions have been studied at four different temperatures between 30 to 45ºC. A mechanism involving the complex formation between catalyst and oxidant has been proposed. [1-carboxy cyclohexane1-acetic acid] acid has been identified chromatographically and spectroscopically as the final product of oxidation of gabapentin. Based on the kinetic data, reaction stoichiometry and product analysis, a reaction mechanism has been proposed and rate law has been derived

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2018-02-28

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Volume 4, Issue 1, January-February-2018

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Research Articles

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[1]
Reena Patel, Shailesh Kumar, Abhishek Verma, Sheila Srivastava, " Microamount of Pd(II) Catalyzed Oxidation of Nuroleptic Drug (Gabapentin) by Potassium Bromated (KBrO3) in Perchloric (HCIO4) Acid Medium : A Kinetic Study, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 1, pp.207-213, January-February-2018.