Synthesis, Characterization and Antimicrobial Analysis Of Various Substituted 6-(3-(5-Bromothiophen-2-Yl)-1-Phenyl-1H-Pyrazol-4-Yl)-4-(2-Hydroxyphenyl) Pyrimidine-2(1H)-Thiones

Authors

  • Sunil S. Bhagat  Department of Chemistry, R. B. Attal Arts, Science and Commerce College, Georai,Beed, Maharashtra, India
  • Balaji D. Rupnar  Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India
  • Amol J. Shirsat  
  • Charansingh H. Gill  

Keywords:

Chromones, Pyrazolopyrimidines, Antimicrobial Activity

Abstract

The title compounds thiopyrimidines 3(a-h) have been synthesized from chromones 1(a-h) by refluxing thiourea 2 with potassium hydroxide. The structures of all newly synthesized compounds have been confirmed by IR, 1H NMR and Mass spectral data. The synthesized compounds have been screened for their antimicrobial activity. Some of the compounds show moderate antimicrobial activity as compared to the reference drugs Ciprofloxacin and Fluconazole.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2018-01-22

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Volume 4, Issue 3, January-February-2018

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Research Articles

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Sunil S. Bhagat, Balaji D. Rupnar, Amol J. Shirsat, Charansingh H. Gill "Synthesis, Characterization and Antimicrobial Analysis Of Various Substituted 6-(3-(5-Bromothiophen-2-Yl)-1-Phenyl-1H-Pyrazol-4-Yl)-4-(2-Hydroxyphenyl) Pyrimidine-2(1H)-Thiones" International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 3, pp.01-03, January-February-2018.