Synthesis of Some Novel Chlorochromones Containing Pyrazole Moiety

Authors

  • Amol J. Shirsat  Department of Chemistry, R. B. Attal Arts, Science & Commerce College, Georai, Beed, Maharashtra, India
  • Sunil S. Bhagat  Department of Chemistry, R. B. Attal Arts, Science & Commerce College, Georai, Beed, Maharashtra, India
  • Balaji D. Rupnar  Department of Chemistry, R. B. Attal Arts, Science & Commerce College, Georai, Beed, Maharashtra, India
  • Gopal K. Kakade  Department of Chemistry, Arts, Commerce & Science College, Kille- Dharur, Beed, Maharashtra, India

Keywords:

Chalcones, Chlorochromones, Antimicrobial, Gram +Ve And Gram –Ve Microorganisms.

Abstract

A mild and proficient method has been developed for the synthesis of chlorochromones from oxidative cyclization of chalcones. High yield, simple workup procedure and mild reaction condition are main feature of this method. All synthesized chlorochromones has been evaluated for their antimicrobial activity against Gram +ve and Gram –ve microorganisms.

References

  1. Wiley P F; J Am Chem Soc,4 (1952) 4329.
  2. Jongerbreur G; Arch Intern Pharmacodynamic,90 (1952) 384. b) Schmitz J,Hirt R,Eichenberger F E and Lavener H H; Helv Chim Acta 36 (1953) 620. c) Wander A G; Brit Pat,27 (1955) 4329.
  3. Donnelly D,Geoghegen R,Brein O,Phibin E and Wheeler T S; J Med Chem,8 (6) (1965) 872.
  4. Kelly D. R.,Carroff E.,Lood R. W. F.,Heal W. and Roberts S. M.,Chem Commun,2004; 2016.
  5. Sam Solomon W. D.,Ravi T. K. and Annadurai K.,Indian Drugs,1999; 36(7),466.
  6. Mokle SS,Sayeed MA,Kothawar C. Synthesis and antimicrobial activity of some chalcone derivatives. International Journal of Chemical Sciences 2004; 2 (1): 96-100.
  7. Gammill R. B.,Synthesis,1979; 901.
  8. Randhavane P,Karale B. Synthesis and biological screening of some fluorinated dibenzofuran containing 3- chlorochromones and benzothiazepines. Journal of Heterocyclic Chemistry 2009; 46(4): 732-736.
  9. Madje B R,Shindalkar S. S.,Ware M. N. and Shingare M. S.,Arkivoc,2005; 14,82.
  10. Gerwick W. H.,Lopez A.,Van Duyne G. D.,Clardy J.,Ortiz W. and Buez A.,Tetrahedron Lett,1979; 270,1986.

International Journal of Scientific Research in Science, Engineering and Technology

Downloads

Published

2018-01-22

Issue

Volume 4, Issue 3, January-February-2018

Section

Research Articles

License

Copyright (c) IJSRSET

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Amol J. Shirsat, Sunil S. Bhagat, Balaji D. Rupnar, Gopal K. Kakade "Synthesis of Some Novel Chlorochromones Containing Pyrazole Moiety" International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 3, pp.40-42, January-February-2018.