Synthetic Strategy, Characterization and Antimycobacterium Evaluation of 8-Hydroxy Quinoline Derivatives

Authors

  • Perumal Sarojini  Department of Chemistry, Sri S. Ramasamy Naidu Memorial College, Sattur, Virudhunagar, Tamil Nadu, India.
  • Malaichamy Jeyachandran  Post Graduate and Research Department of Chemistry, Sri Paramakalyani College, Alwarkurichi, Tirunelveli, Tamil Nadu, India
  • Vagolusivakrishna  Department of Pharmacy,Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad, India
  • Dharmarajan Sriram  Department of Pharmacy,Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad, India

Keywords:

8-hydroxyquinolines, Synthetic statergy, In vitro antimycobacterial activity, MTB MABA assay

Abstract

8-hydroxyquinoline derivatives are privileged structures for the design of new drug candidates. Due to its synthetic versatility, it holds many biological activities such as antibacterial, antifungal, immunosuppressive, analgesic, vasorelaxing, antiplasmodial, anticancer and antimycobacterium activity. In the present study, a series of 3-(substituted aryl)-1-(quinolin-8-yloxy) propan-2-ol were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against mycobacterium tuberculosis H37Ra. A significant decrease of mycobacterial cell metabolism (viability of M. tuberculosis H37Ra) was observed using MTB MABA assay. The structures of the compounds are elucidated with the aid of fourier transform infrared, proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance spectral techniques.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2018-04-30

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Volume 4, Issue 4, March-April-2018

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Research Articles

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[1]
Perumal Sarojini, Malaichamy Jeyachandran, Vagolusivakrishna, Dharmarajan Sriram "Synthetic Strategy, Characterization and Antimycobacterium Evaluation of 8-Hydroxy Quinoline Derivatives" International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 4, Issue 4, pp.571-575, March-April-2018.