Synthetic Strategy, Characterization and Antimycobacterium Evaluation of 8-Hydroxy Quinoline Derivatives
Keywords:
8-hydroxyquinolines, Synthetic statergy, In vitro antimycobacterial activity, MTB MABA assayAbstract
8-hydroxyquinoline derivatives are privileged structures for the design of new drug candidates. Due to its synthetic versatility, it holds many biological activities such as antibacterial, antifungal, immunosuppressive, analgesic, vasorelaxing, antiplasmodial, anticancer and antimycobacterium activity. In the present study, a series of 3-(substituted aryl)-1-(quinolin-8-yloxy) propan-2-ol were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against mycobacterium tuberculosis H37Ra. A significant decrease of mycobacterial cell metabolism (viability of M. tuberculosis H37Ra) was observed using MTB MABA assay. The structures of the compounds are elucidated with the aid of fourier transform infrared, proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance spectral techniques.
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