Design and Synthesis of Novel Antimicrobial and Antitubercular 4-thiazolidinones

Abstract

A series of new 4-thiazolidinone derivatives was designed, synthesized and screened for their antimicrobial activity and antitubercular activity. The structures of the compounds were elucidated with the aid of IR, 1H NMR, mass spectroscopy, and elemental analysis. The antimicrobial activity of the compounds was tested against four bacterial strains (Staphylococcus aureus MTCC 443 and Staphylococcus pyogenus MTCC 443, Escherichia coli MTCC 442 and Pseudomonas aeruginosa MTCC 443) and three fungal strains (Candida albicans MTCC 227, Aspergillus niger MTCC 282, Aspergillus clavatus MTCC 1323). The title compounds were also investigated for their antitubercular activity against M. tuberculosis H37Rv (MTCC 200) strain using L. J. agar dilution method.