Synthesis and Antimicrobial Evaluation of Some Condensed New pyrimido [1,2-a] benzimidazole

Authors

  • Jatin Vora  Department of Chemistry, Sheth L. H. Science College, Mansa, India (Scholars of Gujarat University, Ahmedabad), Gujarat, India
  • Kartik Vyas  Department of Chemistry, Sheth L. H. Science College, Mansa, Gujarat, India

DOI:

https://doi.org//10.32628/IJSRSET207269

Keywords:

4-(benzyloxy)-3-methoxybenzaldehyde, N-(substituted phenyl)-3-oxobutanamide and 2H-1,2,4-triazol-3-amine and N,N’-di methyl formamide

Abstract

An efficient synthesis of a novel compound series of 2-[3,5-bis(trifluoromethyl)phenyl]-4-(substitutedphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole (Biginelli reaction) was accomplished from (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-chlorophenyl)prop-2-en-1-one and 1H-benzo[d]imidazol-2-amine Microwave 25 minute heating after the product obtained another method Conventional 7 hrs, with 30 % KOH, Ethanol. Here (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-chlorophenyl)prop-2-en-1-one(Chalcone) is prepared by 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde with Claisen-Schimidt Condensation.All the newly synthesized compounds were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2019-05-30

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Volume 6, Issue 3, May-June-2019

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Research Articles

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How to Cite

[1]
Jatin Vora, Kartik Vyas, " Synthesis and Antimicrobial Evaluation of Some Condensed New pyrimido [1,2-a] benzimidazole, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 6, Issue 3, pp.397-404, May-June-2019. Available at doi : https://doi.org/10.32628/IJSRSET207269