Synthesis and Antibacterial Studies of New Metal Complexes of 1, 3, 4-Oxadiazole derivatives (NODMHQ)

Authors

  • Rajesh Kumar A. Chauhan  Sheth L. H. Science College, Mansa, Gujarat, India
  • Kaushik A. Joshi  D K V Arts & Science College, Jamnagar, Gujarat, India
  • Vipul N. Joshi  D K V Arts & Science College, Jamnagar, Gujarat, India
  • Ram N. Nandaniya  Shri P.H.G. Muni. Arts & Science College, Kalol, Gujarat, India

Keywords:

5-((4-nitrophenoxy) methyl)-3-(((8-hydroxyquinolin-5-yl) amino) methyl)-1,3,4-oxadiazole-2(3H)-thione, Spectroscopies study, Magnetic moment, Antifungal properties.

Abstract

Mannich reaction between 5-amino-8-quinolinol (AMQ) and 5-(4-nitrophenoxy methyl acetyl)-1,3,4-oxadiazole-2(3H)-thione (NOD) in the presence of formaldehyde was gave 5-((4-notrophenoxy)methyl)-3-(((8-hydroxyquinolin-5-yl)amino)methyl)-1,3,4-oxadiazole-2(3H)-thione (NODMHQ), which was characterized by elemental analysis and spectral studies. The transition metal chelates viz. Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of the product were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The antifungal activity of that synthesized compound and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents.

References

  1. A. Husain, M. Ajmal, Acta Pharm., 2009,59,223.
  2. H.Kumar, S. A. Javed, S.A.Khan, M. Amir, European Journal of Medicinal Chemistry,2008,43,2688e2698.
  3. K.Manjunatha,B.Poojary,P.L.Lobo,J.Fernandes, N.S.Umari,European Journal of Medicinal Chemistry,2010,45,5225e5233.
  4. M.Akhter, A.Husain,B. Azad, M.Ajmal,European Journal of Medicinal Chemistry,2009,44,2372.
  5. B. Jayashankar, K. M. Lokanath Rai , N. Baskaran, H.S. Sathish,European Journal of Medicinal Chemistry, 2009,44,3898.
  6. T.Chandra, N.Garg, S.Lata, K.K.Saxena, A.Kumar, European Journal of Medicinal Chemistry,2010,45,1772.
  7. A.S. Aboraia, H.M. Abdel-Rahman,N. M. Mahfouz and M.A. EL-Gendy, Bioorganic & Medicinal Chemistry,2006,14,1236.
  8. L.Jin, J.Chen, B.Song, Z.Chen, S.Yang, Q.Li,D.Hu and R.Xu, Bioorganic & Medicinal Chemistry Letters,2006,16,5036.
  9. Q.Zheng, X.Zhang, Y.Xu,K.Cheng, Q.Jiao, H.Liang Zhu,Bioorganic & Medicinal Chemistry,2010,18,7836.
  10. K.A.Kumar, P.Jayaroopa,G.V.Kumar, International Journal of ChemTech Research, 2012,4(4)4,1782.
  11. M.M.Raikhshtat,S.B.Savvin and L.A. Gribov,Zh Anal. Khim.,1979,34,1886.
  12. L.A.Gribov, S.B.Savvin and M.M.Raikhshtat,Zh. Anal. Khim.,1980,35,1469.
  13. K.A. Oster and M.J.Golden,J. Am. Phrm. Assoc. Sci. Ed., 1947,37,283.
  14. K.A. Oster and M.J.Golden,Exp. Med. Surg.,1949,37.
  15. J.P. Philips, Chem. Review,1984,56, 271.
  16. J.H. Barkhater and R.I.Teib, J.Org.Chem.,1968,26,4078.
  17. A.Kenichiro, T. Zaaea and T. Sakurasaaea, seni Gakkaiski,2001,57,229.
  18. T.D. Portanna, B.P.Anana, and Z.A.Rajvin,Visakamol soedin,1975,17,120.
  19. L.Katshutoshi and L.Hideki,Japan patent,1998,1017953.
  20. W.Abraham, K.Rami and P.Abrahaks,U.S.Patent,1976,4317887.
  21. A.D.Dunya, S.J.Sukhina, V.G.Sinyavskii and Y.P. Kabrak,Ukr. Khim zh., 1982, 48,1087.
  22. C. Xiamren,F.Yushi, L.Hisann, H.Kazuhisa and A.Kusabbura, Anal. Sci, 1955,11,313.
  23. Patel,D.K and Singh,A.,E-journal of chemistry,6(4),1017(2009).
  24. K. K. Oza, H. S. Patel, Bulgarian Chemical Communications,2010,42(2),103.
  25. P.Mishra, V. Jatav and S.K. Kashaw, J. India Chem. Soc., 2006,83,1165.
  26. A.I.Vogel,Textbook of Quantitative Chemical Analysis, ELBS 5th Edn. London, 1996.
  27. W.R. Baily and E.G. Scott, Diagnostic Microbiology, The C. V. Moshy Co. St. Lovis,1966, 257.
  28. B. R. Patil, Oriental J.Chem.,2006,18,547.

International Journal of Scientific Research in Science, Engineering and Technology

Downloads

Published

2019-03-30

Issue

Volume 6, Issue 2, March-April-2019

Section

Research Articles

License

Copyright (c) IJSRSET

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Rajesh Kumar A. Chauhan, Kaushik A. Joshi, Vipul N. Joshi, Ram N. Nandaniya, " Synthesis and Antibacterial Studies of New Metal Complexes of 1, 3, 4-Oxadiazole derivatives (NODMHQ), International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 6, Issue 2, pp.820-824, March-April-2019.