Synthesis, Characterization and Biological Evaluation Of 2-Chloroquinoline-Tetramethyl-Hexahydro- 1H-xanthene-1,8-(2H) Dione Derivatives

Authors

  • Arun Vaghasiya  Department of Chemistry, M.V.M. Science and Home Science College, Rajkot, Gujarat, India
  • Chetana Rajyaguru  Department of Chemistry, M.V.M. Science and Home Science College, Rajkot, Gujarat, India
  • Kaushik Joshi  Department of Chemistry, D.K.V. Arts and Science College, Jamnagar, Gujarat, India
  • Govind Kher  Department of Chemistry, Tolani College of Arts and Science, Adipur, Gujarat, India
  • Jatin Upadhiyay  Department of Chemistry, M.V.M. Science and Home Science College, Rajkot, Gujarat, India

Keywords:

2-chloro-5,8-dimethylquinoline-3-carbaldehyde, 5,5-dimethylcyclohexane-1,3-dione, HCl.

Abstract

9-(2-chloro-substitutedquinolin-3-yl)-3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-2H-xanthene-1,8(5H,9H)-diones (DMDMO-1 to 12) were prepared with good yield by very effective method using the basic idea with quite novel approach 2-chloro-5,8-dimethylquinoline-3-carbaldehyde and 5,5-dimethylcyclohexane-1,3-dione was refluxed for 12 to 18 hrs. in presence of HCl. Completion of reaction was checked by thin layer chromatographic (TLC) technique. All the new synthesized compounds authorized with better functional group and derivatizations were characterized by IR, 1HNMR and elemental analyses. All the synthesized compounds were assessed for their antimicrobial activity.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2019-05-30

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Volume 6, Issue 3, May-June-2019

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Research Articles

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[1]
Arun Vaghasiya, Chetana Rajyaguru, Kaushik Joshi, Govind Kher, Jatin Upadhiyay, " Synthesis, Characterization and Biological Evaluation Of 2-Chloroquinoline-Tetramethyl-Hexahydro- 1H-xanthene-1,8-(2H) Dione Derivatives, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 6, Issue 3, pp.420-426, May-June-2019.