Development of Validated UV Spectrophotometric Method for Assay of Ozagrel

Authors

  • Dr. D. S. Ghotekar  Department of Chemistry, N.V.P.Mandal’s, Arts, Commerce and Science College Lasalgaon Tal-Niphad, Dist-Nashik, Maharastra, India

Keywords:

Ozagrel, validation, UV-Spectrophometry.

Abstract

Abstract: UV Spectrophotometric method was developed and validated for the quantitative determination of Ozagrel in bulk drug and in pharmaceutical formulations. Ozagrel shows the maximum absorbance at 270 nm. Ozagrel follows Beer’s law in the concentration range of 1.0-10.0 µg/ml (r = 0.999). The detection limit (DL) and quantitation limit (QL) were 0.4629 and 1.4027 µg/ml respectively. Accuracy and precision were found to be satisfactory. The developed methods were validated according to ICH guidelines. All the validation parameters were found to be satisfactory accordance with the standard values. Therefore, the proposed method can be used for routine practice for the determination of Ozagrel in assay of bulk drug and pharmaceutical formulations.

References

  1. ICH, Q2 (R1): “Validation of Analytical Procedures: Text and Methodology” In Proceedings the International Conference on Harmonisation; IFPMA, Geneva, 2005.
  2. United State Pharmacopoeia 30-National Formulary 25. In Validation of compendial procedures, Chapter 1225, 2007, p. 549.
  3. Rui1 JIN, SUN-xiang2 Kao, Zhen1 WANG, HAN Yu-bo1. “Pharmacokinetic Study on Ozagrel in Twelve Healthy Volunteers.” Chinese Pharmaceutical Journal, 2006, 41(04), p. 296-298.
  4. Sujit Kumar Debnath, S. Saisivam, Dillip Kumar Dash and Monalisha Debnath, “Development and validation of UV-spectrophotometric methods for quantitative estimation of Prothionamide in pure and pharmaceutical dosage forms”, International Current Pharmaceutical Journal, June 2015, 4(7): 402-404
  5. Vishal N Kushare, Sagar V Ghotekar. Development of a Validated Stability Indicating RP- HPLC Method for Assay of Ozagrel and Its Pharmaceutical Formulations, International Journal of Pharmacy and Pharmaceutical Research. January 2019 Vol.: 14, Issue: 2.pg.no 46 to 65
  6. Vishal N Kushare, Sachin S Kushare, Development of Validated Stability Indicating HPTLC Method for Assay of Ozagrel and its Pharmaceutical Formulations, International Journal of Scientific Research in Science, Engineering and Technology. November- December-2018 [4 (11): 36 to 48]
  7. Vishal N Kushare, Sachin S. Kushare, Sagar V Ghotekar Development of Validated UV Spectrophotometric Method for Assay of Ozagrel and its Pharmaceutical Formulations. International Journal of Scientific Research in Science, Engineering and Technology. November-December-2018 [4 (11): 69 to 77]
  8. Vishal N. Kushare, Sagar V. Ghotekar, Morade V.B, Salade J. N, Preparation of Transdermal Patch and Evaluation of Physical Parameters, International Journal of Scientific Research in Science, Engineering and Technology.January-February-2019 [6 (1): 01 to 04]
  9. Vishal N. Kushare, Pritishchandra S.Kabra, Overview to Drug Development Process International Journal of Scientific Research in Science, Engineering and Technology. September-October-2019 [6 (5): 70 to 73]
  10. Dr.D.S.Ghotekar, Vishal N. Kushare, Validated Stability Indicating HPTLC of Clopidogrel and its Pharmaceutical Formulations. International Journal of Scientific Research in Science, Engineering and Technology.January-February-2019 [6 (1): 557 to 567]
  11. Dr.D.S.Ghotekar, Vishal N. Kushare, Assay of Clopidogrel by Using HPLTC Method. Journal of Scientific Research in Science and Technology. (www.ijsrst.com) November-December-2018 [4 (11): 557 to 561]
  12. Dr.D.S.Ghotekar, Vishal N. Kushare, Preparation and Characterization of Atenolol Base from Hydrochloric Salt. Our Heritage, Vol-68-Issue-1-January -2020, Page no. 11102 to 11107.
  13. Dr.D.S.Ghotekar, Vishal N Kushare, Ultrasound Promoted Synthesis and Characterization of Some Chalcones, Chromones and 1, 5 Benzothiazepines as Antibacterial and Antifungal Agent, Our Heritage, Vol-68-Issue-1-January -2020, Page No.11117 to 11124.
  14. Dr.D.S.Ghotekar, Vishal N. Kushare, 'Development of a Validated Stability Indicating RP-HPLC Method for Assay of Clopidogrel', Journal of Scientific Research in Science And Technology. (www.ijsrst.com) March-April-2019. [6 (2):834 to 838]
  15. Vishal N Kushare, Sagar V Ghotekar. Principles of analytical chemistry to drug Analysis & Stability Indicating Assay Method (SIAM), International Journal of Scientific Research in Chemistry (www.ijsrch.com). July-August- 2020. Vol.5, Issue: 4. pg.no.24 To 28
  16. Dr.D.S.Ghotekar, Vishal N. Kushare, 'Validated Stability Indicating HPTLC of Paracetamol’. Journal of Scientific Research in Science and Technology. (www.ijsrst.com) November-December-2017 [3 (4): 581 to 586]

International Journal of Scientific Research in Science, Engineering and Technology

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Published

2020-12-30

Issue

Volume 7, Issue 6, November-December-2020

Section

Research Articles

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How to Cite

[1]
Dr. D. S. Ghotekar "Development of Validated UV Spectrophotometric Method for Assay of Ozagrel " International Journal of Scientific Research in Science, Engineering and Technology (IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 7, Issue 6, pp.316-321, November-December-2020.