Chemistry and biological evaluation of some new 1,2,3,4-tetrahydro-n-(substitutedphenyl)-6-methyl-2-oxo-4-[3-phenyl-1-(pyridine-4-carbonyl)-1h-pyrazol-4-yl]pyrimidine-5-carboxamide

Authors

  • Chetan C. Rathod  Department of Chemistry, Shri Jagdishprasad Jhabarmal Tibrewala University in Jhunjhunu, Rajasthan, India
  • Manish J. Solanki  C. U. Shah Science College Ahmedabad, Gujarat, India
  • Haresh K. Ram  Department of Chemistry, Tolani College of Arts & Science, Adipur, Gujarat, India

Keywords:

3-phenyl-1-(pyridin-4-ylcarbonyl)-1-H-pyrazole-4-carbaldehyde, urea, substituted aceto- acetanilide, ethanol and conc. HCl.

Abstract

An proficient Synthesis of a novel series of Chemistry and biological evaluation of some new 1,2,3,4-tetrahydro-n-(substitutedphenyl)-6-methyl-2-oxo-4-[3-phenyl-1-(pyridine-4-carbonyl)-1h-pyrazol-4-yl]pyrimidine-5-carboxamide (4a-j) was accomplished from 3-phenyl-1-(pyridin-4-ylcarbonyl)-1-H-pyrazole-4-carbaldehyde, substituted aceto-acetanilide and in acidic medium. and then after the cooling product was obtained. All the recently synthesized compounds were characterized by the Mass, IR, 1H-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were assessed for their antibacterial and antifungal activity.

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International Journal of Scientific Research in Science, Engineering and Technology

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Published

2019-05-30

Issue

Volume 6, Issue 3, May-June-2019

Section

Research Articles

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How to Cite

[1]
Chetan C. Rathod, Manish J. Solanki, Haresh K. Ram, " Chemistry and biological evaluation of some new 1,2,3,4-tetrahydro-n-(substitutedphenyl)-6-methyl-2-oxo-4-[3-phenyl-1-(pyridine-4-carbonyl)-1h-pyrazol-4-yl]pyrimidine-5-carboxamide, International Journal of Scientific Research in Science, Engineering and Technology(IJSRSET), Print ISSN : 2395-1990, Online ISSN : 2394-4099, Volume 6, Issue 3, pp.427-433, May-June-2019.