Effect Flavonoids Rich Fraction of Mucuna Pruriens Leaf on Blood Glucose, Liver Function Indices and Lipid Profile of Alloxan-Induced Diabetes in RATS

Abstract

Diabetes mellitus is spreading in an alarming way throughout the world and considered as a major cause of high economic loss which can in turn impede the development of nations. Moreover, uncontrolled diabetes lead to many chronic complications such as blindness, heart disease, renal failure, etc. This present study checked the effect of flavonoid fraction of Mucuna pruriens leaves on blood glucose level, liver function indices and lipid profile of alloxan induced diabetes in rats Diabetes was induced by intraperitoneal injection of Alloxan monohydrate (130 mg/kg b w) to rats. The rats were randomly divided into the following groups (n = 6). Group I (normal control) received distilled water, group II received 5 mg/kg b w glibenclamide, Group III (diabetic control) received distilled water, group IV, V and VI received 200, 400 and 600 mg/kg b w of the flavonoids fraction of Mucuna puriens (FFMU), respectively orally once daily for 14 days. The study showed that there was a significant reduction (p<0.05) in the blood glucose level. The serum levels of TC, TG, LDL-C, AST, ALT and ALP were significantly reduced in the alloxan-induced diabetic treated groups. There was remarkable increased in HDL-C of alloxan-induced diabetic treated groups. The result shows that the FFMU may be useful in the management of secondary complications associated with diabetes mellitus.