Plant Juice Catalysed Synthesis of Substituted Pyrrole through Paal Knorr Reaction
DOI:
https://doi.org/10.32628/IJSRSET2411586Keywords:
Hexane-2, 5-dione, Aniline, Pyrrole, Kalanchoe Pinnata JuiceAbstract
The current research work proposed the novel methodology for the synthesis of N-substituted pyrrole catalysed by juice of Kalanchoe Pinnata plant leaves. The reaction was carried out between hexan 2,5 dione and aniline. This protocol is environmentally benign cost effective and fruitful which has produced the desired product in short reaction time and easy work up. The synthesised compounds has been confirmed by 1HNMR , IR and C13 spectroscopy. The natural abundance, cost effective, non toxic and good to excellent yields are some specific features of this catalyst.
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Sheikh, A. A., Patel S.K., Kasim, S.S., 2020.Efficient and Environmentally Benign Synthesis of Quinoxaline Catalysed by Fruit Juice. Int. J. Sci. Res. Chemi. 5 (1):01-05
M. Shaikh, M. Shaikh, A. A. Sheikh, S.S. Kasim. Synthesis of 4-Aryl-2-Aminothiazole Using Onion Extract: A Green Chemistry Approach. Heterocyclic Letters. 2021, 11,53-58.
Shaikh, A. A., Shaikh F.,Kasim S.S., 2018. Grape Juice Catalyzed Synthesis of Substituted Pyrrole by Paal-Knorr Reaction. Int. J. Res. Cult. Soc. 4(5) : 31-35.
Sheikh, A. A., Asif M. Kasim S.S., 2018. Lemon Juice Catalyzed Synthesis of N-substituted Pyrrole by Paal-Knorr Reaction. Int. J. S. Res. Sci. Engg. Technol, 4(10) :176-180.
Majid Shaikh , Mujahed Shaikh , Devendra Wagare , Anis Ahmed Sheikh Kasim S S.2022 Current Catalysis,11, 65-70. Deep Eutectic Solvent (DES) Mediated Multicomponent Synthesis of 4-Thiazolidinone-5-carboxylic Acid: A Green Chemistry Approach. DOI: https://doi.org/10.2174/2211544711666220610163447
Aiello, A., Esposito, D., Fattorusso, M., Menna, E., Müeller, M., Perovi, W.E.G., Ottstadt, S., Tsuruta, H., Gulder, T.A.M. and Bringmann, G. (2005). Tetrahedron. 61(30),7266 – 7270 DOI: https://doi.org/10.1016/j.tet.2005.05.025
Sun, X.T. and Chen, A. (2007). Tetrahedron Lett. 48(19),3459 – 3461. DOI: https://doi.org/10.1016/j.tetlet.2007.03.022
Woo, J.C.S. and MacKay, D.B. (2003). Tetrahedron Lett. 44(14),2881 – 2883. DOI: https://doi.org/10.1016/S0040-4039(03)00431-3
Bhardawj, V.; Gumber, D.; Aboot, V.; Dhiman, S.; Sharma, P. Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics. RSC Adv. 2015, 5, 15233– 15266, DOI: 10.1039/c4ra15710a. DOI: https://doi.org/10.1039/C4RA15710A
Manderville, R.A.(2001) Curr. Med. Chem.:Anti-Cancer Agents. 1(2),195-218. DOI: https://doi.org/10.2174/1568011013354688
Hantzsch, A. (1890). Ber. Dtsch. Chem. Ges. (23), 1474. DOI: https://doi.org/10.1002/cber.189002301242
Knorr, L. (1884). Ber. Dtsch. Chem. Ges. (17), 1635. DOI: https://doi.org/10.1002/cber.18840170220
Paal, C. (1885). Ber. Dtsch. Chem. Ges., (18), 367. DOI: https://doi.org/10.1002/cber.18850180175
Aqueous Microwave-Assisted Chemistry, ed. V. Polshetti-war and R. S. Varma, RSC Publishing, Cambridge, 2010;
M. Abid, A. Spaeth and B. Török, Adv. Synth. Catal., 2006, 348, 2191; A. Solan, B. Nişanci, M. Belcher, J. Young, C. Schäfer, K. A. Wheeler, B. Török and R. Dembinski, Green Chem., 2014, 16, 1120.
Afzal M, Kazmi I, Khan R, Singh R, Chauhan M, Bisht T, Anwar F. Bryophyllum pinnatum: A review. Int J Res Biol Sci, 2012b; 2: 143-149.
Asiedu-Gyekye IJ, Antwi DA, Bugyei KA, Awortwe C. Comparative study of two Kalanchoe species: Total flavonoid, phenolic contents and antioxidant properties. Afr J Pure Appl Chem, 2012;6: 65-73. DOI: https://doi.org/10.5897/AJPAC11.088
Biswas D, Mondal TK. Evaluation of anti-pyretic activity of hydroalcoholic extract of Kalanchoe pinnata leaves against yeast-induced pyrexia in rat. Int. J. Innovat. Pharm. Sci Res, 2015; 3: 483-49.
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