Nanoengineered Copper: Revolutionizing Breast Cancer Care
DOI:
https://doi.org/10.32628/IJSRSET25121162Keywords:
Nanoparticles in Oncology, Nanoengineered Copper, Breast Cancer Therapy, Photothermal and Photodynamic Therapy, Targeted Drug DeliveryAbstract
Breast cancer continues to rank as a predominant cause of illness and death among women globally, emphasizing the critical need for innovative and effective treatment approaches. Traditional methods such as chemotherapy, surgery, and radiation therapy often face limitations, including toxicity, resistance, and non-specific targeting. In recent years, advancements in nanotechnology have brought about transformative solutions, with nanoengineered copper emerging as a frontrunner. Nanoengineered copper’s unique properties- including its catalytic capabilities, biocompatibility, and potential for surface modification- offer unprecedented opportunities to revolutionize breast cancer care. These nanoparticles not only enable precise targeting of cancer cells but also improve diagnostic accuracy through advanced imaging techniques. Furthermore, their application in photothermal and photodynamic therapies provides a dual approach to destroying cancer cells while minimizing harm to healthy tissues. With the ability to modulate the tumor microenvironment and act as a platform for combination therapies, nanoengineered copper holds immense promise for both early detection and effective treatment. This article explores the wide-ranging applications of nanoengineered copper, from diagnostic innovations to therapeutic breakthroughs, underscoring its potential to redefine breast cancer management and improve patient outcomes.
Downloads
References
C. H. Barrios, “Global challenges in breast cancer detection and treatment,” The Breast, vol. 62, pp. S3–S6, Mar. 2022, doi: 10.1016/j.breast.2022.02.003. DOI: https://doi.org/10.1016/j.breast.2022.02.003
D. Trapani et al., “Global challenges and policy solutions in breast cancer control,” Cancer Treat. Rev., vol. 104, p. 102339, Mar. 2022, doi: 10.1016/j.ctrv.2022.102339. DOI: https://doi.org/10.1016/j.ctrv.2022.102339
L. Wilkinson and T. Gathani, “Understanding breast cancer as a global health concern,” Br. J. Radiol., vol. 95, no. 1130, p. 20211033, Feb. 2022, doi: 10.1259/bjr.20211033. DOI: https://doi.org/10.1259/bjr.20211033
S. A. Ahmed, M. H. Gaber, A. A. Salama, and S. A. Ali, “Efficacy of copper nanoparticles encapsulated in soya lecithin liposomes in treating breast cancer cells (MCF-7) in vitro,” Sci. Rep., vol. 13, no. 1, p. 15576, Sep. 2023, doi: 10.1038/s41598-023-42514-2.
J. G. Dos Santos Batista et al., “Copper-Based Nanomaterials for Biologically Relevant Compounds,” in ACS Symposium Series, vol. 1466, A. Srivastava and A. Srivastava, Eds., Washington, DC: American Chemical Society, 2024, pp. 305–338. doi: 10.1021/bk-2024-1466.ch012.
R. Khursheed et al., “Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives,” Biomed. Pharmacother., vol. 150, p. 112951, Jun. 2022, doi: 10.1016/j.biopha.2022.112951. DOI: https://doi.org/10.1016/j.biopha.2022.112951
A. G. Krishna, S. Sahana, H. Venkatesan, and V. Arul, “Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges,” J. Egypt. Natl. Cancer Inst., vol. 36, no. 1, p. 44, Dec. 2024, doi: 10.1186/s43046-024-00254-y.
L. Leena Panigrahi et al., “Nanoparticle-mediated diagnosis, treatment, and prevention of breast cancer,” Nanoscale Adv., vol. 6, no. 15, pp. 3699–3713, 2024, doi: 10.1039/D3NA00965C.
G. Naikoo et al., “An Overview of Copper Nanoparticles: Synthesis, Characterisation and Anticancer Activity,” Curr. Pharm. Des., vol. 27, no. 43, pp. 4416–4432, Dec. 2021, doi: 10.2174/1381612827666210804100303.
C. Surya et al., “Advancements in breast cancer therapy: The promise of copper nanoparticles,” J. Trace Elem. Med. Biol., vol. 86, p. 127526, Dec. 2024, doi: 10.1016/j.jtemb.2024.127526.
B. S. George, E. I. Mfon, and N. M. Etim, “Development and Utilization of Nanotechnology in Medicine and the Built Environment.,” Feb. 2024, doi: 10.5281/ZENODO.10616806.
M. Harun-Ur-Rashid, I. Jahan, T. Foyez, and A. B. Imran, “Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications,” Micromachines, vol. 14, no. 9, p. 1786, Sep. 2023, doi: 10.3390/mi14091786. DOI: https://doi.org/10.3390/mi14091786
B. K. Kashyap, V. V. Singh, M. K. Solanki, A. Kumar, J. Ruokolainen, and K. K. Kesari, “Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities,” ACS Omega, vol. 8, no. 16, pp. 14290–14320, Apr. 2023, doi: 10.1021/acsomega.2c07840. DOI: https://doi.org/10.1021/acsomega.2c07840
T. T. Truong et al., “Precision-engineered metal and metal-oxide nanoparticles for biomedical imaging and healthcare applications,” Adv. Colloid Interface Sci., vol. 332, p. 103263, Oct. 2024, doi: 10.1016/j.cis.2024.103263. DOI: https://doi.org/10.1016/j.cis.2024.103263
J. G. Dos Santos Batista et al., “Copper-Based Nanomaterials for Biologically Relevant Compounds,” in ACS Symposium Series, vol. 1466, A. Srivastava and A. Srivastava, Eds., Washington, DC: American Chemical Society, 2024, pp. 305–338. doi: 10.1021/bk-2024-1466.ch012.
G. Naikoo et al., “An Overview of Copper Nanoparticles: Synthesis, Characterisation and Anticancer Activity,” Curr. Pharm. Des., vol. 27, no. 43, pp. 4416–4432, Dec. 2021, doi: 10.2174/1381612827666210804100303.
C. Surya et al., “Advancements in breast cancer therapy: The promise of copper nanoparticles,” J. Trace Elem. Med. Biol., vol. 86, p. 127526, Dec. 2024, doi: 10.1016/j.jtemb.2024.127526.
M. J. Woźniak-Budych, K. Staszak, and M. Staszak, “Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges,” Molecules, vol. 28, no. 18, p. 6687, Sep. 2023, doi: 10.3390/molecules28186687.
M. Al-zharani et al., “Antitumor effect of copper nanoparticles on human breast and colon malignancies,” Environ. Sci. Pollut. Res., vol. 28, no. 2, pp. 1587–1595, Jan. 2021, doi: 10.1007/s11356-020-09843-5.
L. Dou, X. Zhang, M. M. Zangeneh, and Y. Zhang, “Efficient biogenesis of Cu2O nanoparticles using extract of Camellia sinensis leaf: Evaluation of catalytic, cytotoxicity, antioxidant, and anti-human ovarian cancer properties,” Bioorganic Chem., vol. 106, p. 104468, Jan. 2021, doi: 10.1016/j.bioorg.2020.104468. DOI: https://doi.org/10.1016/j.bioorg.2020.104468
P. R. Prasad, S. Kanchi, and E. B. Naidoo, “In-vitro evaluation of copper nanoparticles cytotoxicity on prostate cancer cell lines and their antioxidant, sensing and catalytic activity: One-pot green approach,” J. Photochem. Photobiol. B, vol. 161, pp. 375–382, Aug. 2016, doi: 10.1016/j.jphotobiol.2016.06.008. DOI: https://doi.org/10.1016/j.jphotobiol.2016.06.008
A. Vodyashkin, A. Stoinova, and P. Kezimana, “Promising biomedical systems based on copper nanoparticles: Synthesis, characterization, and applications,” Colloids Surf. B Biointerfaces, vol. 237, p. 113861, May 2024, doi: 10.1016/j.colsurfb.2024.113861. DOI: https://doi.org/10.1016/j.colsurfb.2024.113861
M. Alhajj and S. K. Ghoshal, “Sustainability, safety, biocompatibility and benefits of laser ablated gold, silver and copper nanoparticles: A comprehensive review,” J. Mol. Liq., vol. 414, p. 126130, Nov. 2024, doi: 10.1016/j.molliq.2024.126130. DOI: https://doi.org/10.1016/j.molliq.2024.126130
C. Surya et al., “Advancements in breast cancer therapy: The promise of copper nanoparticles,” J. Trace Elem. Med. Biol., vol. 86, p. 127526, Dec. 2024, doi: 10.1016/j.jtemb.2024.127526.
M. J. Woźniak-Budych, K. Staszak, and M. Staszak, “Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges,” Molecules, vol. 28, no. 18, p. 6687, Sep. 2023, doi: 10.3390/molecules28186687.
M. Azizi, H. Ghourchian, F. Yazdian, F. Dashtestani, and H. AlizadehZeinabad, “Cytotoxic effect of albumin coated copper nanoparticle on human breast cancer cells of MDA-MB 231,” PLOS ONE, vol. 12, no. 11, p. e0188639, Nov. 2017, doi: 10.1371/journal.pone.0188639.
V. Rahimkhoei, A. H. Alzaidy, M. J. Abed, S. Rashki, and M. Salavati-Niasari, “Advances in inorganic nanoparticles-based drug delivery in targeted breast cancer theranostics,” Adv. Colloid Interface Sci., vol. 329, p. 103204, Jul. 2024, doi: 10.1016/j.cis.2024.103204.
H. Xu et al., “Copper-Based Nanomaterials for Image-Guided Cancer Therapy,” BIO Integr., vol. 5, no. 1, 2024, doi: 10.15212/bioi-2024-0013.
K. Babu Busi et al., “The Multifarious Applications of Copper Nanoclusters in Biosensing and Bioimaging and Their Translational Role in Early Disease Detection,” Nanomaterials, vol. 12, no. 3, p. 301, Jan. 2022, doi: 10.3390/nano12030301.
Y. Han, N. Xie, and W. Zhou, “Copper Coordination‐Based Nanomedicine for Tumor Theranostics,” Adv. Ther., vol. 7, no. 2, p. 2300305, Feb. 2024, doi: 10.1002/adtp.202300305.
H. Xu et al., “Copper-Based Nanomaterials for Image-Guided Cancer Therapy,” BIO Integr., vol. 5, no. 1, 2024, doi: 10.15212/bioi-2024-0013. DOI: https://doi.org/10.15212/bioi-2024-0013
M. H. Karami, M. Abdouss, and B. Maleki, “The state of the art metal nanoparticles in drug delivery systems: A comprehensive review,” Nanomedicine J., vol. 11, no. 3, Jul. 2024, doi: 10.22038/nmj.2024.77638.1895.
N. Mamidi, R. M. V. Delgadillo, A. O. Sustaita, K. Lozano, and M. M. Yallapu, “Current nanocomposite advances for biomedical and environmental application diversity,” Med. Res. Rev., p. med.22082, Sep. 2024, doi: 10.1002/med.22082. DOI: https://doi.org/10.1002/med.22082
J. Patel, G. S. Kumar, H. Roy, B. Maddiboyina, S. Leporatti, and R. A. Bohara, “From nature to nanomedicine: bioengineered metallic nanoparticles bridge the gap for medical applications,” Discov. Nano, vol. 19, no. 1, p. 85, May 2024, doi: 10.1186/s11671-024-04021-9. DOI: https://doi.org/10.1186/s11671-024-04021-9
G. R. Rudramurthy and M. K. Swamy, “Potential applications of engineered nanoparticles in medicine and biology: an update,” JBIC J. Biol. Inorg. Chem., vol. 23, no. 8, pp. 1185–1204, Dec. 2018, doi: 10.1007/s00775-018-1600-6. DOI: https://doi.org/10.1007/s00775-018-1600-6
M. J. Woźniak-Budych, K. Staszak, and M. Staszak, “Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges,” Molecules, vol. 28, no. 18, p. 6687, Sep. 2023, doi: 10.3390/molecules28186687.
J. G. Dos Santos Batista et al., “Copper-Based Nanomaterials for Biologically Relevant Compounds,” in ACS Symposium Series, vol. 1466, A. Srivastava and A. Srivastava, Eds., Washington, DC: American Chemical Society, 2024, pp. 305–338. doi: 10.1021/bk-2024-1466.ch012.
Y. Han, N. Xie, and W. Zhou, “Copper Coordination‐Based Nanomedicine for Tumor Theranostics,” Adv. Ther., vol. 7, no. 2, p. 2300305, Feb. 2024, doi: 10.1002/adtp.202300305.
L. Leena Panigrahi et al., “Nanoparticle-mediated diagnosis, treatment, and prevention of breast cancer,” Nanoscale Adv., vol. 6, no. 15, pp. 3699–3713, 2024, doi: 10.1039/D3NA00965C. DOI: https://doi.org/10.1039/D3NA00965C
S.-R. Li, S.-Y. Tao, Q. Li, C.-Y. Hu, and Z.-J. Sun, “Harnessing nanomaterials for copper-induced cell death,” Biomaterials, vol. 313, p. 122805, Feb. 2025, doi: 10.1016/j.biomaterials.2024.122805.
X. Zhong, X. Dai, Y. Wang, H. Wang, H. Qian, and X. Wang, “Copper‐based nanomaterials for cancer theranostics,” WIREs Nanomedicine Nanobiotechnology, vol. 14, no. 4, p. e1797, Jul. 2022, doi: 10.1002/wnan.1797.
A. Amorim et al., “Copper nanoparticles stabilized with cashew gum: Antimicrobial activity and cytotoxicity against 4T1 mouse mammary tumor cell line,” J. Biomater. Appl., vol. 34, no. 2, pp. 188–197, Aug. 2019, doi: 10.1177/0885328219845964.
M. Azizi, H. Ghourchian, F. Yazdian, F. Dashtestani, and H. AlizadehZeinabad, “Cytotoxic effect of albumin coated copper nanoparticle on human breast cancer cells of MDA-MB 231,” PLOS ONE, vol. 12, no. 11, p. e0188639, Nov. 2017, doi: 10.1371/journal.pone.0188639.
G. F. Galal, B. T. Abd-Elhalim, K. A. Abou-Taleb, A. A. Haroun, and R. F. Gamal, “Toxicity assessment of green synthesized Cu nanoparticles by cell-free extract of Pseudomonas silesiensis as antitumor cancer and antimicrobial,” Ann. Agric. Sci., vol. 66, no. 1, pp. 8–15, Jun. 2021, doi: 10.1016/j.aoas.2021.01.006. DOI: https://doi.org/10.1016/j.aoas.2021.01.006
U. Jinu, M. Gomathi, I. Saiqa, N. Geetha, G. Benelli, and P. Venkatachalam, “Green engineered biomolecule-capped silver and copper nanohybrids using Prosopis cineraria leaf extract: Enhanced antibacterial activity against microbial pathogens of public health relevance and cytotoxicity on human breast cancer cells (MCF-7),” Microb. Pathog., vol. 105, pp. 86–95, Apr. 2017, doi: 10.1016/j.micpath.2017.02.019. DOI: https://doi.org/10.1016/j.micpath.2017.02.019
J. G. Dos Santos Batista et al., “Copper-Based Nanomaterials for Biologically Relevant Compounds,” in ACS Symposium Series, vol. 1466, A. Srivastava and A. Srivastava, Eds., Washington, DC: American Chemical Society, 2024, pp. 305–338. doi: 10.1021/bk-2024-1466.ch012.
A. G. Krishna, S. Sahana, H. Venkatesan, and V. Arul, “Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges,” J. Egypt. Natl. Cancer Inst., vol. 36, no. 1, p. 44, Dec. 2024, doi: 10.1186/s43046-024-00254-y.
M. J. Woźniak-Budych, K. Staszak, and M. Staszak, “Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges,” Molecules, vol. 28, no. 18, p. 6687, Sep. 2023, doi: 10.3390/molecules28186687.
S. Ghosh, B. P. Singh, and T. J. Webster, “Nanoparticle-impregnated biopolymers as novel antimicrobial nanofilms,” in Biopolymer-Based Nano Films, Elsevier, 2021, pp. 269–309. doi: 10.1016/B978-0-12-823381-8.00017-X. DOI: https://doi.org/10.1016/B978-0-12-823381-8.00017-X
O. M. Khubiev, A. R. Egorov, A. A. Kirichuk, V. N. Khrustalev, A. G. Tskhovrebov, and A. S. Kritchenkov, “Chitosan-Based Antibacterial Films for Biomedical and Food Applications,” Int. J. Mol. Sci., vol. 24, no. 13, p. 10738, Jun. 2023, doi: 10.3390/ijms241310738. DOI: https://doi.org/10.3390/ijms241310738
M. Omidiyan, P. Srinoi, P. Tajalli, and T. R. Lee, “Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices,” ACS Appl. Nano Mater., vol. 7, no. 8, pp. 8377–8391, Apr. 2024, doi: 10.1021/acsanm.3c05173. DOI: https://doi.org/10.1021/acsanm.3c05173
O. Sedighi, B. Bednarke, H. Sherriff, and A. L. Doiron, “Nanoparticle-Based Strategies for Managing Biofilm Infections in Wounds: A Comprehensive Review,” ACS Omega, vol. 9, no. 26, pp. 27853–27871, Jul. 2024, doi: 10.1021/acsomega.4c02343. DOI: https://doi.org/10.1021/acsomega.4c02343
J. G. Dos Santos Batista et al., “Copper-Based Nanomaterials for Biologically Relevant Compounds,” in ACS Symposium Series, vol. 1466, A. Srivastava and A. Srivastava, Eds., Washington, DC: American Chemical Society, 2024, pp. 305–338. doi: 10.1021/bk-2024-1466.ch012.
Y. Han, N. Xie, and W. Zhou, “Copper Coordination‐Based Nanomedicine for Tumor Theranostics,” Adv. Ther., vol. 7, no. 2, p. 2300305, Feb. 2024, doi: 10.1002/adtp.202300305.
Y.-N. Hao, W.-X. Zhang, Y.-R. Gao, Y.-N. Wei, Y. Shu, and J.-H. Wang, “State-of-the-art advances of copper-based nanostructures in the enhancement of chemodynamic therapy,” J. Mater. Chem. B, vol. 9, no. 2, pp. 250–266, 2021, doi: 10.1039/D0TB02360D.
S.-R. Li, S.-Y. Tao, Q. Li, C.-Y. Hu, and Z.-J. Sun, “Harnessing nanomaterials for copper-induced cell death,” Biomaterials, vol. 313, p. 122805, Feb. 2025, doi: 10.1016/j.biomaterials.2024.122805.
A. Mohapatra, S. Uthaman, and I.-K. Park, “External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy,” Front. Mol. Biosci., vol. 7, p. 597634, Jan. 2021, doi: 10.3389/fmolb.2020.597634. DOI: https://doi.org/10.3389/fmolb.2020.597634
X. Zhong, X. Dai, Y. Wang, H. Wang, H. Qian, and X. Wang, “Copper‐based nanomaterials for cancer theranostics,” WIREs Nanomedicine Nanobiotechnology, vol. 14, no. 4, p. e1797, Jul. 2022, doi: 10.1002/wnan.1797.
A. Antonio-Pérez, L. F. Durán-Armenta, M. G. Pérez-Loredo, and A. L. Torres-Huerta, “Biosynthesis of Copper Nanoparticles with Medicinal Plants Extracts: From Extraction Methods to Applications,” Micromachines, vol. 14, no. 10, p. 1882, Sep. 2023, doi: 10.3390/mi14101882.
F. A. El-Shenawy, E. M. El. El-Sherbeny, and S. Kassem, “Efficacy of zinc oxide and copper oxide nanoparticles on virulence genes of avian pathogenic E. coli (APEC) in broilers,” BMC Vet. Res., vol. 19, no. 1, p. 108, Aug. 2023, doi: 10.1186/s12917-023-03643-y. DOI: https://doi.org/10.1186/s12917-023-03643-y
A. G. Krishna, S. Sahana, H. Venkatesan, and V. Arul, “Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges,” J. Egypt. Natl. Cancer Inst., vol. 36, no. 1, p. 44, Dec. 2024, doi: 10.1186/s43046-024-00254-y.
J. I. Lachowicz, L. I. Lecca, F. Meloni, and M. Campagna, “Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy,” Molecules, vol. 26, no. 21, p. 6639, Nov. 2021, doi: 10.3390/molecules26216639. DOI: https://doi.org/10.3390/molecules26216639
S.-R. Li, S.-Y. Tao, Q. Li, C.-Y. Hu, and Z.-J. Sun, “Harnessing nanomaterials for copper-induced cell death,” Biomaterials, vol. 313, p. 122805, Feb. 2025, doi: 10.1016/j.biomaterials.2024.122805.
G. Vimbela, S. M. Ngo, C. Fraze, L. Yang, and D. A. Stout, “Antibacterial properties and toxicity from metallic nanomaterials,” Int. J. Nanomedicine, vol. Volume 12, pp. 3941–3965, May 2017, doi: 10.2147/IJN.S134526. DOI: https://doi.org/10.2147/IJN.S134526
L. O. Abdelhakm, E. I. Kandil, S. Z. Mansour, and S. M. El-Sonbaty, “Chrysin Encapsulated Copper Nanoparticles with Low Dose of Gamma Radiation Elicit Tumor Cell Death Through p38 MAPK/NF-κB Pathways,” Biol. Trace Elem. Res., vol. 201, no. 11, pp. 5278–5297, Nov. 2023, doi: 10.1007/s12011-023-03596-1. DOI: https://doi.org/10.1007/s12011-023-03596-1
M. Al-zharani et al., “Antitumor effect of copper nanoparticles on human breast and colon malignancies,” Environ. Sci. Pollut. Res., vol. 28, no. 2, pp. 1587–1595, Jan. 2021, doi: 10.1007/s11356-020-09843-5. DOI: https://doi.org/10.1007/s11356-020-09843-5
A. A. Hassabo, E. I. Ibrahim, B. A. Ali, and H. E. Emam, “Anticancer effects of biosynthesized Cu2O nanoparticles using marine yeast,” Biocatal. Agric. Biotechnol., vol. 39, p. 102261, Jan. 2022, doi: 10.1016/j.bcab.2021.102261. DOI: https://doi.org/10.1016/j.bcab.2021.102261
M. J. Javid-Naderi et al., “Advancements in nanocarrier-mediated sunitinib delivery: Addressing obstacles and revealing its therapeutic promise in oncological treatment,” J. Drug Deliv. Sci. Technol., vol. 100, p. 106107, Oct. 2024, doi: 10.1016/j.jddst.2024.106107. DOI: https://doi.org/10.1016/j.jddst.2024.106107
K. Babu Busi et al., “The Multifarious Applications of Copper Nanoclusters in Biosensing and Bioimaging and Their Translational Role in Early Disease Detection,” Nanomaterials, vol. 12, no. 3, p. 301, Jan. 2022, doi: 10.3390/nano12030301. DOI: https://doi.org/10.3390/nano12030301
A. G. Krishna, S. Sahana, H. Venkatesan, and V. Arul, “Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges,” J. Egypt. Natl. Cancer Inst., vol. 36, no. 1, p. 44, Dec. 2024, doi: 10.1186/s43046-024-00254-y.
J. M. Neilio and D. T. Ginat, “Emerging Head and Neck Tumor Targeting Contrast Agents for the Purpose of CT, MRI, and Multimodal Diagnostic Imaging: A Molecular Review,” Diagnostics, vol. 14, no. 15, p. 1666, Aug. 2024, doi: 10.3390/diagnostics14151666. DOI: https://doi.org/10.3390/diagnostics14151666
S. Tsymbal et al., “Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics,” Molecules, vol. 27, no. 20, p. 7066, Oct. 2022, doi: 10.3390/molecules27207066. DOI: https://doi.org/10.3390/molecules27207066
X. Zhong, X. Dai, Y. Wang, H. Wang, H. Qian, and X. Wang, “Copper‐based nanomaterials for cancer theranostics,” WIREs Nanomedicine Nanobiotechnology, vol. 14, no. 4, p. e1797, Jul. 2022, doi: 10.1002/wnan.1797.
M. Zhou, M. Tian, and C. Li, “Copper-Based Nanomaterials for Cancer Imaging and Therapy,” Bioconjug. Chem., vol. 27, no. 5, pp. 1188–1199, May 2016, doi: 10.1021/acs.bioconjchem.6b00156.
G. Fan, X. Li, S. Xu, C. Dai, Q. Xue, and H. Wang, “SERS-based copper-mediated signal amplification strategy for simple and sensitive detection of telomerase activity,” Talanta, vol. 235, p. 122814, Dec. 2021, doi: 10.1016/j.talanta.2021.122814. DOI: https://doi.org/10.1016/j.talanta.2021.122814
A. Kapara, “Imaging of breast cancer using SERS and SESORS,” University of Strathclyde, 2019. doi: 10.48730/87M3-P927.
Z. Wang, S. Wu, L. Colombi Ciacchi, and G. Wei, “Graphene-based nanoplatforms for surface-enhanced Raman scattering sensing,” The Analyst, vol. 143, no. 21, pp. 5074–5089, 2018, doi: 10.1039/C8AN01266K. DOI: https://doi.org/10.1039/C8AN01266K
S. Xu et al., “Graphene/Cu Nanoparticle Hybrids Fabricated by Chemical Vapor Deposition As Surface-Enhanced Raman Scattering Substrate for Label-Free Detection of Adenosine,” ACS Appl. Mater. Interfaces, vol. 7, no. 20, pp. 10977–10987, May 2015, doi: 10.1021/acsami.5b02303. DOI: https://doi.org/10.1021/acsami.5b02303
C. Yang et al., “Shell-isolated graphene@Cu nanoparticles on graphene@Cu substrates for the application in SERS,” Carbon, vol. 98, pp. 526–533, Mar. 2016, doi: 10.1016/j.carbon.2015.11.042. DOI: https://doi.org/10.1016/j.carbon.2015.11.042
Q. Zhou et al., “Detection of Circulating Tumor DNA in Human Blood via DNA-Mediated Surface-Enhanced Raman Spectroscopy of Single-Walled Carbon Nanotubes,” Anal. Chem., vol. 88, no. 9, pp. 4759–4765, May 2016, doi: 10.1021/acs.analchem.6b00108. DOI: https://doi.org/10.1021/acs.analchem.6b00108
M. Azizi, H. Ghourchian, F. Yazdian, F. Dashtestani, and H. AlizadehZeinabad, “Cytotoxic effect of albumin coated copper nanoparticle on human breast cancer cells of MDA-MB 231,” PLOS ONE, vol. 12, no. 11, p. e0188639, Nov. 2017, doi: 10.1371/journal.pone.0188639.
S. S. Biresaw and P. Taneja, “Copper nanoparticles green synthesis and characterization as anticancer potential in breast cancer cells (MCF7) derived from Prunus nepalensis phytochemicals,” Mater. Today Proc., vol. 49, pp. 3501–3509, 2022, doi: 10.1016/j.matpr.2021.07.149. DOI: https://doi.org/10.1016/j.matpr.2021.07.149
A. G. Krishna, S. Sahana, H. Venkatesan, and V. Arul, “Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges,” J. Egypt. Natl. Cancer Inst., vol. 36, no. 1, p. 44, Dec. 2024, doi: 10.1186/s43046-024-00254-y.
G. Naikoo et al., “An Overview of Copper Nanoparticles: Synthesis, Characterisation and Anticancer Activity,” Curr. Pharm. Des., vol. 27, no. 43, pp. 4416–4432, Dec. 2021, doi: 10.2174/1381612827666210804100303.
S. A. Ahmed, M. H. Gaber, A. A. Salama, and S. A. Ali, “Efficacy of copper nanoparticles encapsulated in soya lecithin liposomes in treating breast cancer cells (MCF-7) in vitro,” Sci. Rep., vol. 13, no. 1, p. 15576, Sep. 2023, doi: 10.1038/s41598-023-42514-2.
J. G. Dos Santos Batista et al., “Copper-Based Nanomaterials for Biologically Relevant Compounds,” in ACS Symposium Series, vol. 1466, A. Srivastava and A. Srivastava, Eds., Washington, DC: American Chemical Society, 2024, pp. 305–338. doi: 10.1021/bk-2024-1466.ch012.
Y. Han, N. Xie, and W. Zhou, “Copper Coordination‐Based Nanomedicine for Tumor Theranostics,” Adv. Ther., vol. 7, no. 2, p. 2300305, Feb. 2024, doi: 10.1002/adtp.202300305. DOI: https://doi.org/10.1002/adtp.202300305
Y.-N. Hao, W.-X. Zhang, Y.-R. Gao, Y.-N. Wei, Y. Shu, and J.-H. Wang, “State-of-the-art advances of copper-based nanostructures in the enhancement of chemodynamic therapy,” J. Mater. Chem. B, vol. 9, no. 2, pp. 250–266, 2021, doi: 10.1039/D0TB02360D. DOI: https://doi.org/10.1039/D0TB02360D
X. Zhong, X. Dai, Y. Wang, H. Wang, H. Qian, and X. Wang, “Copper‐based nanomaterials for cancer theranostics,” WIREs Nanomedicine Nanobiotechnology, vol. 14, no. 4, p. e1797, Jul. 2022, doi: 10.1002/wnan.1797. DOI: https://doi.org/10.1002/wnan.1797
M. Zhou, M. Tian, and C. Li, “Copper-Based Nanomaterials for Cancer Imaging and Therapy,” Bioconjug. Chem., vol. 27, no. 5, pp. 1188–1199, May 2016, doi: 10.1021/acs.bioconjchem.6b00156. DOI: https://doi.org/10.1021/acs.bioconjchem.6b00156
A. Amorim et al., “Copper nanoparticles stabilized with cashew gum: Antimicrobial activity and cytotoxicity against 4T1 mouse mammary tumor cell line,” J. Biomater. Appl., vol. 34, no. 2, pp. 188–197, Aug. 2019, doi: 10.1177/0885328219845964. DOI: https://doi.org/10.1177/0885328219845964
A. Dehnoee, R. Javad Kalbasi, M. M. Zangeneh, M.-R. Delnavazi, and A. Zangeneh, “Characterization, Anti-lung Cancer Activity, and Cytotoxicity of Bio-synthesized Copper Nanoparticles by Thymus fedtschenkoi Leaf Extract,” J. Clust. Sci., vol. 35, no. 3, pp. 863–874, Mar. 2024, doi: 10.1007/s10876-023-02512-w. DOI: https://doi.org/10.1007/s10876-023-02512-w
A. Mohapatra, P. Sathiyamoorthy, and I.-K. Park, “Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy,” Pharmaceutics, vol. 13, no. 11, p. 1867, Nov. 2021, doi: 10.3390/pharmaceutics13111867. DOI: https://doi.org/10.3390/pharmaceutics13111867
P. Taherzadeh-Soureshjani and M. Chehelgerdi, “Algae-meditated route to cuprous oxide (Cu2O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer,” Cancer Nanotechnol., vol. 11, no. 1, p. 11, Dec. 2020, doi: 10.1186/s12645-020-00066-4. DOI: https://doi.org/10.1186/s12645-020-00066-4
T. Xing, Z. Wang, X. Hao, J. Mu, and B. Wang, “Copper Nanoparticles Green-Formulated by Curcuma longa Extract Induce Apoptosis via P53 and STAT3 Signaling Pathways in Bladder Carcinoma Cell,” Biol. Trace Elem. Res., Oct. 2024, doi: 10.1007/s12011-024-04373-4. DOI: https://doi.org/10.1007/s12011-024-04373-4
L. Zhao, Y. Gui, J. Cai, and X. Deng, “Biometallic ions and derivatives: a new direction for cancer immunotherapy,” Mol. Cancer, vol. 24, no. 1, p. 17, Jan. 2025, doi: 10.1186/s12943-025-02225-w. DOI: https://doi.org/10.1186/s12943-025-02225-w
S. Abdolmaleki, A. Aliabadi, and S. Khaksar, “Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review,” J. Cancer Res. Clin. Oncol., vol. 150, no. 4, p. 213, Apr. 2024, doi: 10.1007/s00432-024-05641-5. DOI: https://doi.org/10.1007/s00432-024-05641-5
C. Surya et al., “Advancements in breast cancer therapy: The promise of copper nanoparticles,” J. Trace Elem. Med. Biol., vol. 86, p. 127526, Dec. 2024, doi: 10.1016/j.jtemb.2024.127526. DOI: https://doi.org/10.1016/j.jtemb.2024.127526
S. A. Ahmed, M. H. Gaber, A. A. Salama, and S. A. Ali, “Efficacy of copper nanoparticles encapsulated in soya lecithin liposomes in treating breast cancer cells (MCF-7) in vitro,” Sci. Rep., vol. 13, no. 1, p. 15576, Sep. 2023, doi: 10.1038/s41598-023-42514-2. DOI: https://doi.org/10.1038/s41598-023-42514-2
M. Azizi, H. Ghourchian, F. Yazdian, F. Dashtestani, and H. AlizadehZeinabad, “Cytotoxic effect of albumin coated copper nanoparticle on human breast cancer cells of MDA-MB 231,” PLOS ONE, vol. 12, no. 11, p. e0188639, Nov. 2017, doi: 10.1371/journal.pone.0188639. DOI: https://doi.org/10.1371/journal.pone.0188639
A. K. Bidan and Z. S. A. Al-Ali, “The role of biomaterial constituents of Jasminum sambac (L.) Aiton leaves in copper nanoparticles synthesis and evaluates their activities as anti-breast cancer and antibacterial agents,” Inorg. Nano-Met. Chem., pp. 1–16, Jun. 2024, doi: 10.1080/24701556.2024.2354480. DOI: https://doi.org/10.1080/24701556.2024.2354480
A. Chinnathambi, T. Awad Alahmadi, and S. Ali Alharbi, “Biogenesis of copper nanoparticles (Cu-NPs) using leaf extract of Allium noeanum , antioxidant and in-vitro cytotoxicity,” Artif. Cells Nanomedicine Biotechnol., vol. 49, no. 1, pp. 500–510, Jan. 2021, doi: 10.1080/21691401.2021.1926275. DOI: https://doi.org/10.1080/21691401.2021.1926275
A. G. Krishna, S. Sahana, H. Venkatesan, and V. Arul, “Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges,” J. Egypt. Natl. Cancer Inst., vol. 36, no. 1, p. 44, Dec. 2024, doi: 10.1186/s43046-024-00254-y. DOI: https://doi.org/10.1186/s43046-024-00254-y
M. J. Woźniak-Budych, K. Staszak, and M. Staszak, “Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges,” Molecules, vol. 28, no. 18, p. 6687, Sep. 2023, doi: 10.3390/molecules28186687. DOI: https://doi.org/10.3390/molecules28186687
B. D. Harishchandra et al., “Copper Nanoparticles: A Review on Synthesis, Characterization and Applications,” Asian Pac. J. Cancer Biol., vol. 5, no. 4, pp. 201–210, Dec. 2020, doi: 10.31557/apjcb.2020.5.4.201-210. DOI: https://doi.org/10.31557/apjcb.2020.5.4.201-210
V. Rahimkhoei, A. H. Alzaidy, M. J. Abed, S. Rashki, and M. Salavati-Niasari, “Advances in inorganic nanoparticles-based drug delivery in targeted breast cancer theranostics,” Adv. Colloid Interface Sci., vol. 329, p. 103204, Jul. 2024, doi: 10.1016/j.cis.2024.103204. DOI: https://doi.org/10.1016/j.cis.2024.103204
C. M. Luque-Jacobo et al., “Biogenic Synthesis of Copper Nanoparticles: A Systematic Review of Their Features and Main Applications,” Molecules, vol. 28, no. 12, p. 4838, Jun. 2023, doi: 10.3390/molecules28124838. DOI: https://doi.org/10.3390/molecules28124838
S. B. Mali, “Copper Nanoparticles—Potential for Cancer Therapy,” J. Maxillofac. Oral Surg., Nov. 2024, doi: 10.1007/s12663-024-02374-3.
D. Rosenblum, N. Joshi, W. Tao, J. M. Karp, and D. Peer, “Progress and challenges towards targeted delivery of cancer therapeutics,” Nat. Commun., vol. 9, no. 1, p. 1410, Apr. 2018, doi: 10.1038/s41467-018-03705-y. DOI: https://doi.org/10.1038/s41467-018-03705-y
A. Antonio-Pérez, L. F. Durán-Armenta, M. G. Pérez-Loredo, and A. L. Torres-Huerta, “Biosynthesis of Copper Nanoparticles with Medicinal Plants Extracts: From Extraction Methods to Applications,” Micromachines, vol. 14, no. 10, p. 1882, Sep. 2023, doi: 10.3390/mi14101882. DOI: https://doi.org/10.3390/mi14101882
P. J. Gawne, M. Ferreira, M. Papaluca, J. Grimm, and P. Decuzzi, “New opportunities and old challenges in the clinical translation of nanotheranostics,” Nat. Rev. Mater., vol. 8, no. 12, pp. 783–798, Jul. 2023, doi: 10.1038/s41578-023-00581-x. DOI: https://doi.org/10.1038/s41578-023-00581-x
H. Li and T. J. Webster, “Trends in nanomedicine,” in Nanomedicine, Elsevier, 2023, pp. 1–18. doi: 10.1016/B978-0-12-818627-5.00020-8. DOI: https://doi.org/10.1016/B978-0-12-818627-5.00020-8
F. Mazahir, D. Bhogale, A. K. Palai, and A. K. Yadav, “Nanomedicine: Principles, properties, and regulatory issues,” in Smart Polymeric Nano-Constructs in Drug Delivery, Elsevier, 2023, pp. 523–565. doi: 10.1016/B978-0-323-91248-8.00014-3. DOI: https://doi.org/10.1016/B978-0-323-91248-8.00014-3
S. Torres Quintas, A. Canha‐Borges, M. J. Oliveira, B. Sarmento, and F. Castro, “Special Issue: Nanotherapeutics in Women’s Health Emerging Nanotechnologies for Triple‐Negative Breast Cancer Treatment,” Small, p. 2300666, Mar. 2023, doi: 10.1002/smll.202300666. DOI: https://doi.org/10.1002/smll.202300666
T. Ameh and C. M. Sayes, “The potential exposure and hazards of copper nanoparticles: A review,” Environ. Toxicol. Pharmacol., vol. 71, p. 103220, Oct. 2019, doi: 10.1016/j.etap.2019.103220. DOI: https://doi.org/10.1016/j.etap.2019.103220
B. Anima, P. Mondal, G. Gurusubramanian, and V. K. Roy, “Mechanistic study of copper nanoparticle (CuNP) toxicity on the mouse uterus via apelin signaling,” Environ. Sci. Pollut. Res., vol. 30, no. 38, pp. 88824–88841, Jul. 2023, doi: 10.1007/s11356-023-28746-9. DOI: https://doi.org/10.1007/s11356-023-28746-9
J. G. Dos Santos Batista et al., “Copper-Based Nanomaterials for Biologically Relevant Compounds,” in ACS Symposium Series, vol. 1466, A. Srivastava and A. Srivastava, Eds., Washington, DC: American Chemical Society, 2024, pp. 305–338. doi: 10.1021/bk-2024-1466.ch012. DOI: https://doi.org/10.1021/bk-2024-1466.ch012
G. Naikoo et al., “An Overview of Copper Nanoparticles: Synthesis, Characterisation and Anticancer Activity,” Curr. Pharm. Des., vol. 27, no. 43, pp. 4416–4432, Dec. 2021, doi: 10.2174/1381612827666210804100303. DOI: https://doi.org/10.2174/1381612827666210804100303
P. K. Tyagi, A. Arya, A. M. Mazumder, and S. Tyagi, “Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector,” Precis. Nanomedicine, vol. 6, no. 2, Jul. 2023, doi: 10.33218/001c.83932. DOI: https://doi.org/10.33218/001c.83932
S. B. Mali, “Copper Nanoparticles—Potential for Cancer Therapy,” J. Maxillofac. Oral Surg., Nov. 2024, doi: 10.1007/s12663-024-02374-3. DOI: https://doi.org/10.1007/s12663-024-02374-3
Y. Zeng et al., “Inhibiting Osteolytic Breast Cancer Bone Metastasis by Bone‐Targeted Nanoagent via Remodeling the Bone Tumor Microenvironment Combined with NIR‐II Photothermal Therapy,” Small, vol. 19, no. 38, p. 2301003, Sep. 2023, doi: 10.1002/smll.202301003. DOI: https://doi.org/10.1002/smll.202301003
N. Zhang et al., “Biomimetic copper-doped polypyrrole nanoparticles induce glutamine metabolism inhibition to enhance breast cancer cuproptosis and immunotherapy,” J. Controlled Release, vol. 371, pp. 204–215, Jul. 2024, doi: 10.1016/j.jconrel.2024.05.045. DOI: https://doi.org/10.1016/j.jconrel.2024.05.045
S.-R. Li, S.-Y. Tao, Q. Li, C.-Y. Hu, and Z.-J. Sun, “Harnessing nanomaterials for copper-induced cell death,” Biomaterials, vol. 313, p. 122805, Feb. 2025, doi: 10.1016/j.biomaterials.2024.122805. DOI: https://doi.org/10.1016/j.biomaterials.2024.122805
D. Noh, H. Lee, S. Lee, I.-C. Sun, and H. Y. Yoon, “Copper-Based Nanomedicines for Cuproptosis-Mediated Effective Cancer Treatment,” Biomater. Res., vol. 28, p. 0094, Jan. 2024, doi: 10.34133/bmr.0094. DOI: https://doi.org/10.34133/bmr.0094
Downloads
Published
Issue
Section
License
Copyright (c) 2025 International Journal of Scientific Research in Science, Engineering and Technology
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
