Synthesis, Characterization and Biological Activity of Sulphadiazine Schiff Bases of Isatin and their N-Mannich bases

Abstract

Isatin is an endogeneous compounds identified in humans that possesses a wide range og biological activities. It has long range of activities in CNS-MAO inhibition, anticonvulsant and axxiogenie. It effects as a Mao inhibitior is the protent in vitro action. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES , scPTZ and scSTY tests. Various isatin N- mannich bases of isatin-3-thiosemicarbazenes have shown antiviral and tuberculostatic activity. Methisazone is an effective compound against variola and vaccinia viruses. Synthesized N- Mannich bases and hydrazones (Schiff bases) were tested against various bacteria and fungi. Halogen in position -6 and amino moiety in position-1 showed better activity than unsubstitued isatin. Pandeya and coworkers synthesized Schiff bases of isatin withy trimethoprim and their N-Mannich bases. All the synthesized compounds showed good activity against V.Cholerae, S.Boydii, E. faecilis and E. trades with MIC in range of 10-30 ?g/ml.